Impact of human immunodeficiency virus type 1 (HIV-1) subtype on women receiving single-dose nevirapine prophylaxis to prevent HIV-1 vertical transmission (HIV Network for Prevention Trials 012 Study)

Susan H ESHLEMAN; Graziella BECKER-PERGOLA; Martina DESEYVE; Laura A GUAY; Martin MRACNA; Thomas FLEMING; Shawn CUNNINGHAM; Philippa MUSOKE; Francis MMIRO; J. Brooks JACKSON

doi:10.1086/323153

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Impact of human immunodeficiency virus type 1 (HIV-1) subtype on women receiving single-dose nevirapine prophylaxis to prevent HIV-1 vertical transmission (HIV Network for Prevention Trials 012 Study)

Journal article

Open access

Peer reviewed

Impact of human immunodeficiency virus type 1 (HIV-1) subtype on women receiving single-dose nevirapine prophylaxis to prevent HIV-1 vertical transmission (HIV Network for Prevention Trials 012 Study)

Susan H ESHLEMAN, Graziella BECKER-PERGOLA, Martina DESEYVE, Laura A GUAY, Martin MRACNA, Thomas FLEMING, Shawn CUNNINGHAM, Philippa MUSOKE, Francis MMIRO and J. Brooks JACKSON

The Journal of infectious diseases, Vol.184(7), pp.914-917

2001

DOI: 10.1086/323153

PMID: 11509999

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Abstract

In Uganda, the HIV Network for Prevention Trials (HIVNET) 012 study recently demonstrated that single-dose nevirapine (Nvp) prophylaxis is effective for preventing mother-to-child transmission (MTCT) of human immunodeficiency virus type 1 (HIV-1). This exploratory study examines the relationship between HIV-1 subtype, MTCT, and the development of Nvp resistance (Nvp(R)) in women enrolled in HIVNET 012. For 102 women (32 whose infants were HIV-1 infected by age 6-8 weeks and 70 whose infants were uninfected), HIV-1 subtypes included 50 (49%) subtype A, 35 (34%) subtype D, 4 (4%) subtype C, 12 (12%) recombinant subtype, and 1 unclassified. There was no apparent difference in the rate of MTCT among women with subtype A versus D (adjusted odds ratio [OR], 1.24; 95% confidence interval [CI], 0.45-3.43). Nvp(R) mutations were detected more frequently at 6-8 weeks postpartum in women with subtype D than in women with subtype A (adjusted OR, 4.94; 95% CI, 1.21-20.22). Additional studies are needed to further define the relationship between HIV-1 subtype and Nvp(R) among women receiving Nvp prophylaxis.

Infectious Diseases

Microbiology

Virology

Fundamental and applied biological sciences. Psychology

Viral diseases

Viral diseases of the lymphoid tissue and the blood. Aids

Biological and medical sciences

Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies

Medical sciences

Human viral diseases

Details

Title: Subtitle: Impact of human immunodeficiency virus type 1 (HIV-1) subtype on women receiving single-dose nevirapine prophylaxis to prevent HIV-1 vertical transmission (HIV Network for Prevention Trials 012 Study)
Creators: Susan H ESHLEMAN - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States
Graziella BECKER-PERGOLA - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States
Martina DESEYVE - Statistical Center for HIV/AIDS Research and Prevention, Fred Hutchinson Cancer Research Center, United States
Laura A GUAY - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States
Martin MRACNA - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States
Thomas FLEMING - Department of Biostatistics, University of Washington, Seattle, United States
Shawn CUNNINGHAM - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States
Philippa MUSOKE - Department of Paediatrics, Makerere University, Kampala, Uganda
Francis MMIRO - Department of Obstetrics and Gynaccology, Makerere University, Kampala, Uganda
J. Brooks JACKSON - Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, United States
Resource Type: Journal article
Publication Details: The Journal of infectious diseases, Vol.184(7), pp.914-917
DOI: 10.1086/323153
PMID: 11509999
NLM abbreviation: J Infect Dis
ISSN: 0022-1899
eISSN: 1537-6613
Publisher: University of Chicago Press; Chicago, IL
Language: English
Date published: 2001
Academic Unit: Pathology; VPMA - Administration
Record Identifier: 9984047647602771

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