Journal article
Impact of initial biopsy type on the time to final diagnostic biopsy in patients with follicular lymphoma and suspected histologic transformation
Leukemia & lymphoma, Vol.62(12), pp.2864-2872
10/15/2021
DOI: 10.1080/10428194.2021.1941936
PMCID: PMC12318888
PMID: 34176413
Abstract
Diagnosis of histologic transformation (HT) of follicular lymphoma (FL) requires tissue biopsy. While surgical biopsy represents the gold standard, less invasive procedures such as fine-needle aspiration biopsy (FNAB) and core needle biopsy (CNB) are frequently performed. In this retrospective multi-institutional study including 269 patients with FL and suspected HT, the median time from initial clinical suspicion to final diagnostic biopsy was similar whether the workup began with FNAB, CNB, or surgical biopsy (4, 9, and 6 days, respectively; p=.27), despite more subsequent biopsies performed following initial FNAB. Periprocedural complications were uniformly minimal. Biopsy-proven HT was more common in the initial surgery group and in workups including positron emission tomography/computed tomography (PET/CT). Our findings, derived from US academic centers with specialized procedural and pathology expertise, suggest that FNAB, CNB, and surgical biopsy are all viable initial diagnostic procedures that can inform clinical decision-making in select FL patients with suspected HT.
Details
- Title: Subtitle
- Impact of initial biopsy type on the time to final diagnostic biopsy in patients with follicular lymphoma and suspected histologic transformation
- Creators
- Eric Mou - Stanford UniversityLorenzo Falchi - Memorial Sloan Kettering Cancer CenterVandana Sundaram - Stanford UniversityJeremy S. Abramson - Massachusetts General HospitalRonald Balassanian - University of California, San FranciscoSara Beygi - Stanford UniversityMegan J. Fitzpatrick - Massachusetts General HospitalAnnabel Kate Frank - University of California, San FranciscoSrishti Gupta - University of VirginiaOscar Lin - Memorial Sloan Kettering Cancer CenterJoshua R. Reed - Stanford UniversitySteven R. Long - University of California, San FranciscoAmy Ly - Massachusetts General HospitalJoshua R. Menke - Stanford UniversityDaniel R. Reed - University of VirginiaRoberto Ruiz-Cordero - University of California, San FranciscoAshley K. Volaric - University of Virginia Health SystemYi Xie - University of California, San FranciscoLinlin Wang - University of California, San FranciscoKwun Wah Wen - UCSF Helen Diller Family Comprehensive Cancer CenterSara L. Zadeh - University of VirginiaYasodha Natkunam - Stanford UniversityMatthew C. Cheung - Sunnybrook Health Science CentreDita Gratzinger - VA Palo Alto Health Care SystemCyto-Heme Inst Collaborative CHIC
- Resource Type
- Journal article
- Publication Details
- Leukemia & lymphoma, Vol.62(12), pp.2864-2872
- DOI
- 10.1080/10428194.2021.1941936
- PMID
- 34176413
- PMCID
- PMC12318888
- NLM abbreviation
- Leuk Lymphoma
- ISSN
- 1042-8194
- eISSN
- 1029-2403
- Publisher
- Taylor & Francis
- Language
- English
- Date published
- 10/15/2021
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359943402771
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