Journal article
Impact of interleukin IL-6 rs-1474347 and IL-10 rs-1800896 genetic polymorphisms on the susceptibility of HCV-infected Egyptian patients to hepatocellular carcinoma
Immunologic research, Vol.68(3), pp.118-125
2020
DOI: 10.1007/s12026-020-09126-8
PMID: 32504406
Abstract
Hepatitis C virus (HCV) is considered leading cause of cirrhosis and hepatocellular carcinoma (HCC). We aimed to examine the association of IL-6 and IL-10 single-nucleotide polymorphisms with the progression of chronic HCV (CHC) infection to cirrhosis and HCC. For comparative purposes, four groups were enrolled; chronic HCV group (CHC,
n
= 22), HCV-related liver cirrhosis group (HCV-LC,
n
= 22), HCV-related HCC group (HCV-HCC,
n
= 54), and an apparently healthy control group (controls,
n
= 48). HCC diagnosis and staging were in concordance to Barcelona Clinic Liver Cancer (BCLC) staging system. IL-6 rs-1474347 and IL-10 rs-1800896 genotyping was performed by allelic (VIC- and FAM-labeled) discrimination method using assay-on-demand TaqMan real-time PCR assays. For IL-6 rs1474347, the AA genotype was more frequent in CHC, HCV-LC, and HCV-HCC compared to controls. Also, the IL-6 rs1474347 AC genotype was favorable for the progression of HCV chronic infection to cirrhosis and HCC. On the other hand, the IL-10 rs1800896 TT genotype was found to be prominent in the HCC group. Additionally, the IL-10 rs180096 TT genotype was favorable for the progression of chronic HCV infection to cirrhosis and HCC. Furthermore, higher levels of AFP were observed in HCC patients with IL-6 rs1474347 AA genotype and HCC patients with IL-10 rs1800896 CC and TT genotypes. Screening for IL-6 rs 1474347 AC genotype and IL-10 rs180096 TT genotype as well as the determination of AFP level showed to be good markers for examining the susceptibility of HCV Egyptian patients to develop cirrhosis and HCC.
Details
- Title: Subtitle
- Impact of interleukin IL-6 rs-1474347 and IL-10 rs-1800896 genetic polymorphisms on the susceptibility of HCV-infected Egyptian patients to hepatocellular carcinoma
- Creators
- Reham M. Abd El-Baky - Minia UniversityHelal F. Hetta - University of Cincinnati Medical CenterGopala Koneru - University of Cincinnati Medical CenterMarwa Ammar - Sohag UniversityEngy A. Shafik - Assiut UniversityDina A Mohareb - Assiut UniversityMuhammad Abbas El-Masry - Assiut UniversityHaidi K. Ramadan - Assiut UniversityMohamed Zakaria Abu Rahma - Assiut UniversityMichael A. Fawzy - Minia UniversityMoustafa Fathy - Minia University
- Resource Type
- Journal article
- Publication Details
- Immunologic research, Vol.68(3), pp.118-125
- Publisher
- Springer US
- DOI
- 10.1007/s12026-020-09126-8
- PMID
- 32504406
- ISSN
- 0257-277X
- eISSN
- 1559-0755
- Language
- English
- Date published
- 2020
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984359685702771
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