Impact of lung transplantation on serum lipids in COPD

Robert M Reed; Salman Hashmi; Michael Eberlein; Aldo Iacono; Giora Netzer; Andrew DeFilippis; Reda E Girgis; Peter P Toth; Steven Scharf; Steven Jones

doi:10.1016/j.rmed.2011.10.003

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Impact of lung transplantation on serum lipids in COPD

Journal article

Open access

Peer reviewed

Impact of lung transplantation on serum lipids in COPD

Robert M Reed, Salman Hashmi, Michael Eberlein, Aldo Iacono, Giora Netzer, Andrew DeFilippis, Reda E Girgis, Peter P Toth, Steven Scharf and Steven Jones

Respiratory medicine, Vol.105(12), pp.1961-1968

12/2011

DOI: 10.1016/j.rmed.2011.10.003

PMID: 22019328

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Abstract

Severe chronic obstructive pulmonary disease is associated with high HDL cholesterol (HDL-C). We sought to examine the effect of lung transplantation on lipid profiles in patients with COPD. We analyzed 101 lung transplant recipients in a retrospective cohort of patients from two centers in whom lipid values were available both before as well as after transplantation. Sixty-one subjects were transplanted for severe COPD (93% GOLD stage 4). Eighty-nine percent of subjects with COPD exhibited a decline in HDL-C. Median decline for the COPD cohort was 25 mg/dL (IQR 12–38 mg/dL, p < 0.0001). Non-COPD subjects exhibited no significant changes in HDL-C. Other lipid changes in the COPD cohort included a rise in triglycerides of 70 mg/dL (IQR 35 to 140, p < 0.0001). Decreases in HDL-C levels were independent from the rise in triglyceride levels. Neither LDL-C nor non-HDL-C demonstrated significant changes. Subjects with greater increases in prednisone exposure post-transplant exhibited lesser declines in HDL-C. Compared with tacrolimus, cyclosporine had no effect on observed changes in HDL-C or triglycerides, but was associated with a greater median rise in LDL-C. In patients with COPD, lung transplantation results in reductions in the serum levels of HDL-C. These changes are not observed in patients undergoing lung transplantation for diagnoses other than COPD.

HDL

Lipoproteins

Cholesterol

Lung transplantation

COPD

Details

Title: Subtitle: Impact of lung transplantation on serum lipids in COPD
Creators: Robert M Reed - University of Maryland School of Medicine, Division of Pulmonary and Critical Care Medicine, 110 South Paca Street, 2nd Floor, Baltimore, MD 21201, USA
Salman Hashmi - University of Maryland School of Medicine, Division of Pulmonary and Critical Care Medicine, 110 South Paca Street, 2nd Floor, Baltimore, MD 21201, USA
Michael Eberlein - Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, USA
Aldo Iacono - University of Maryland School of Medicine, Division of Pulmonary and Critical Care Medicine, 110 South Paca Street, 2nd Floor, Baltimore, MD 21201, USA
Giora Netzer - University of Maryland School of Medicine, Division of Pulmonary and Critical Care Medicine, 110 South Paca Street, 2nd Floor, Baltimore, MD 21201, USA
Andrew DeFilippis - Johns Hopkins University School of Medicine, Division of Cardiology, USA
Reda E Girgis - Johns Hopkins University School of Medicine, Division of Pulmonary and Critical Care Medicine, USA
Peter P Toth - University of Illinois School of Medicine, Division of Family and Community Medicine, USA
Steven Scharf - University of Maryland School of Medicine, Division of Pulmonary and Critical Care Medicine, 110 South Paca Street, 2nd Floor, Baltimore, MD 21201, USA
Steven Jones - Johns Hopkins University School of Medicine, Division of Cardiology, USA
Resource Type: Journal article
Publication Details: Respiratory medicine, Vol.105(12), pp.1961-1968
Publisher: Elsevier Ltd
DOI: 10.1016/j.rmed.2011.10.003
PMID: 22019328
ISSN: 0954-6111
eISSN: 1532-3064
Language: English
Date published: 12/2011
Academic Unit: Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
Record Identifier: 9984094745702771

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