Impact of male age on the outcome of assisted reproductive technology cycles using donor oocytes

E H Duran; D. Dowling-Lacey; S. Bocca; L. Stadtmauer; S. Oehninger

doi:10.1016/j.rbmo.2010.03.005

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Impact of male age on the outcome of assisted reproductive technology cycles using donor oocytes

Journal article

Peer reviewed

Impact of male age on the outcome of assisted reproductive technology cycles using donor oocytes

E H Duran, D. Dowling-Lacey, S. Bocca, L. Stadtmauer and S. Oehninger

Reproductive biomedicine online, Vol.20(6), pp.848-856

06/01/2010

DOI: 10.1016/j.rbmo.2010.03.005

PMID: 20378414

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Abstract

<p>This study assessed the influence of the age of the male partner on the outcome of oocyte donation cycles. A total of 408 couples participating in 519 consecutive anonymous oocyte donation cycles were examined. Main outcome measures were fertilization rate, embryo quality, clinical pregnancy, implantation, miscarriage and live birth rates, as well as the total reproductive potential, which estimates the outcome from fresh and cryopreserved-thawed embryo transfers. A total of 241 cycles resulted in clinical pregnancy (48.5% of transfers). The mean embryo score for transferred embryos (ESTE) was higher in cycles resulting in pregnancy (P=0.003). Semen volume (P<0.001), sperm motility (P<0.001) and fertilization rate (P=0.04) decreased significantly with advanced male age, which did not correlate with mean ESTE or implantation rate. Fertilization rate was the only predictor of ESTE (B=16.066, P=0.012), whereas inseminated/retrieved egg ratio was the only predictor of implantation rate (B=0.555, P=0.039). Pregnancy was only predicted by ESTE (Exp(B)=1.023, P<0.001), which also was the only predictor of live birth (Exp(B)=1.017, P=0.009). There was no predictor of miscarriage (47 cycles, 9.1%) identified. Although semen volume, sperm motility and fertilization rate decreased with advanced male age, embryo quality, clinical pregnancy, implantation, miscarriage and live birth rates were not affected.</p>

Obstetrics and Gynecology

Adult

Female

Humans

Male

Middle Aged

Oocytes

Ovulation Induction

Reproductive Techniques

Assisted

Details

Title: Subtitle: Impact of male age on the outcome of assisted reproductive technology cycles using donor oocytes
Creators: E H Duran - University of Iowa
D. Dowling-Lacey
S. Bocca
L. Stadtmauer
S. Oehninger
Resource Type: Journal article
Publication Details: Reproductive biomedicine online, Vol.20(6), pp.848-856
DOI: 10.1016/j.rbmo.2010.03.005
PMID: 20378414
NLM abbreviation: Reprod Biomed Online
ISSN: 1472-6491
Language: English
Date published: 06/01/2010
Academic Unit: Obstetrics and Gynecology
Record Identifier: 9983557117002771

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