Impact of nulliparity, hypertensive disorders of pregnancy, and gestational diabetes on vasomotor symptoms in midlife women

Yamnia I Cortés; Rhoda Conant; Janet M Catov; Karen A Matthews; Sybil L Crawford; Monique M Hedderson; Rebecca C Thurston

doi:10.1097/GME.0000000000001628

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Impact of nulliparity, hypertensive disorders of pregnancy, and gestational diabetes on vasomotor symptoms in midlife women

Journal article

Peer reviewed

Impact of nulliparity, hypertensive disorders of pregnancy, and gestational diabetes on vasomotor symptoms in midlife women

Yamnia I Cortés, Rhoda Conant, Janet M Catov, Karen A Matthews, Sybil L Crawford, Monique M Hedderson and Rebecca C Thurston

Menopause (New York, N.Y.), Vol.27(12), pp.1363-1370

12/2020

DOI: 10.1097/GME.0000000000001628

PMCID: 8208832

PMID: 32796290

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https://www.ncbi.nlm.nih.gov/pmc/articles/8208832View

Open Access

Abstract

To determine whether women with a history of nulliparity, hypertensive disorders of pregnancy (HDP), or gestational diabetes mellitus (GDM) have a higher odds of reporting vasomotor symptoms (VMS) at midlife. A longitudinal analysis was performed with 2,249 women with pregnancy history data in the Study of Women's Health Across the Nation. Women were classified as nulliparous, no HDP/GDM, or a history of HDP/GDM. VMS (hot flashes, night sweats) were assessed separately at baseline and at each follow-up visit. VMS was recorded as any versus none; 0 , 1-5 , 6+ days in past 2 weeks. Pregnancy history was examined in relation to each VMS (hot flashes, night sweats) using generalized estimating equations adjusting for age (time-varying), site, race/ethnicity, education, financial strain, smoking, and body mass index. Models excluded women with hysterectomy/bilateral oophorectomy and observations with hormone therapy use. Women in the HDP/GDM group (n = 208, 9%) were more likely to be Black, financially strained, and overweight. Compared to women with no HDP/GDM, women with HDP/GDM had greater odds of reporting any hot flashes (OR:1.27; 95% CI:1.05-1.53). Nulliparous women had lower odds of any hot flashes (OR:0.64; 95% CI:0.51-0.80) and night sweats (OR:0.73; 95% CI:0.58-0.93) in age-adjusted models. Similar patterns were observed for frequency of hot flashes and night sweats; associations were attenuated to nonsignificance after adjusting for covariates. History of HDP/GDM may be associated with more VMS and nulliparity with fewer VMS, but not independently of sociodemographic factors. Our findings underscore the importance of social and economic disparities in both reproductive outcomes and VMS. VIDEO SUMMARY:: http://links.lww.com/MENO/A631.

Diabetes, Gestational - epidemiology

Female

Hot Flashes - epidemiology

Humans

Hypertension, Pregnancy-Induced - epidemiology

Menopause

Parity

Pregnancy

Sweating

Vasomotor System

Details

Title: Subtitle: Impact of nulliparity, hypertensive disorders of pregnancy, and gestational diabetes on vasomotor symptoms in midlife women
Creators: Yamnia I Cortés - University of North Carolina at Chapel Hill
Rhoda Conant - University of Oklahoma Health Sciences Center
Janet M Catov - University of Pittsburgh
Karen A Matthews - University of Pittsburgh
Sybil L Crawford - University of Massachusetts Amherst
Monique M Hedderson - Kaiser Permanente
Rebecca C Thurston - University of Pittsburgh
Resource Type: Journal article
Publication Details: Menopause (New York, N.Y.), Vol.27(12), pp.1363-1370
DOI: 10.1097/GME.0000000000001628
PMID: 32796290
PMCID: 8208832
NLM abbreviation: Menopause
ISSN: 1530-0374
eISSN: 1530-0374
Grant note: U01 AG012539 / NIA NIH HHS U01 AG012531 / NIA NIH HHS U19 AG063720 / NIA NIH HHS U01 AG012535 / NIA NIH HHS
Language: English
Date published: 12/2020
Academic Unit: Nursing
Record Identifier: 9984446446102771

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