Journal article
Impact of pre-operative coronary artery disease on cardiovascular events following lung transplantation
The Journal of heart and lung transplantation, Vol.35(1), pp.115-121
01/2016
DOI: 10.1016/j.healun.2015.08.009
PMID: 26452997
Abstract
This study examined the correlation between pre-operative coronary artery disease (CAD) and post-operative cardiovascular events in lung transplant recipients.
Consecutive isolated lung transplant recipients from 2007 to 2013 in our institution were identified and categorized as having significant CAD (≥ 50% coronary stenosis in at least 1 artery or history of coronary revascularization) or no–mild CAD. Patient records and death index data were analyzed for a median of 2 years for death or cardiovascular events, including coronary, cerebrovascular, and peripheral artery events.
The study comprised 280 patients (62% male) with mean age of 60 ± 10 years. Cardiovascular events occurred in 5.7% (16 of 280) of the entire cohort. Patients with significant CAD had a higher annualized rate of cardiovascular events than those with no–mild CAD (11.9% vs 0.6%; p < 0.001). Significant CAD was an independent predictor of cardiovascular events (hazard ratio, 20.32; 95% confidence interval, 5.79–71.26; p < 0.001) but not all-cause mortality (log-rank p = 0.66). Adding significant CAD to clinical risk factors gave incremental prognostic performance compared with clinical risk factors alone (p < 0.001 for increase in global chi-square).
Selected lung transplant candidates with significant CAD can undergo transplantation with equal mortality risk to those without CAD but are at a higher risk of non-fatal cardiovascular events. These data support the current practice of accepting a selected group of patients with CAD for lung transplantation and suggest that they should be monitored early and treated to prevent cardiovascular complications.
Details
- Title: Subtitle
- Impact of pre-operative coronary artery disease on cardiovascular events following lung transplantation
- Creators
- Kongkiat Chaikriangkrai - Department of MedicineSoma Jyothula - Department of MedicineHye Yeon Jhun - Department of MedicineJerry Estep - Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, TexasMatthias Loebe - Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, TexasScott Scheinin - Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, TexasGuillermo Torre-Amione - Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas
- Resource Type
- Journal article
- Publication Details
- The Journal of heart and lung transplantation, Vol.35(1), pp.115-121
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.healun.2015.08.009
- PMID
- 26452997
- ISSN
- 1053-2498
- eISSN
- 1557-3117
- Language
- English
- Date published
- 01/2016
- Academic Unit
- Gastroenterology and Hepatology; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984094545602771
Metrics
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