Journal article
Impact of radiation on tooth loss in patients with head and neck cancer: a retrospective dosimetric-based study
Oral surgery, oral medicine, oral pathology and oral radiology, Vol.132(4), pp.409-417
10/01/2021
DOI: 10.1016/j.oooo.2021.06.021
PMID: 34366269
Abstract
Objective. To characterize the dental adverse events after head and neck radiation therapy (HNRT) and to investigate the impact of regional radiation dose upon tooth loss outcomes. Study Design. A retrospective dosimetric-based analysis was conducted to assess dental events affecting post-HNRT extracted teeth and the impact of 3 different radiation doses ( 30 Gy, 30-60 Gy, and .001). The odds ratio for post-HNRT tooth extraction risk was approximately 3-fold higher for teeth exposed to 60 Gy (confidence interval, 1.56-5.35; P < .001), followed by an increased risk of delayed healing and osteoradionecrosis (ORN) in sites receiving doses above 50 Gy. Conclusions. Radiation caries was the major cause of dental extractions after HNRT, and the dosimetric analysis suggested that a high dose of radiation may negatively impact the dentition of survivors of head and neck cancer, increasing the risk of tooth loss and ORN. (Oral Surg Oral Med Oral Pathol Oral Radiol 2021;132:409-417)
Details
- Title: Subtitle
- Impact of radiation on tooth loss in patients with head and neck cancer: a retrospective dosimetric-based study
- Creators
- Wagner Gomes-Silva - Universidade de São PauloKarina Morais-Faria - Universidade de São PauloCesar Rivera - Universidade Estadual de Campinas (UNICAMP)Gabriel Faria Najas - Universidade de São PauloGustavo Nader Marta - Universidade de São PauloKarina Gondim Moutinho da Conceicao Vasconcelos - Universidade de São PauloHeloisa de Andrade Carvalho - Universidade de São PauloGilberto de Castro - Instituto do Câncer do Estado de São PauloThais Bianca Brandao - Universidade de São PauloJoel B. Epstein - City Of Hope National Medical CenterAlan Roger Santos-Silva - Universidade Estadual de Campinas (UNICAMP)
- Resource Type
- Journal article
- Publication Details
- Oral surgery, oral medicine, oral pathology and oral radiology, Vol.132(4), pp.409-417
- DOI
- 10.1016/j.oooo.2021.06.021
- PMID
- 34366269
- NLM abbreviation
- Oral Surg Oral Med Oral Pathol Oral Radiol
- ISSN
- 2212-4403
- eISSN
- 2212-4411
- Publisher
- Elsevier
- Number of pages
- 9
- Language
- English
- Date published
- 10/01/2021
- Academic Unit
- Radiation Oncology
- Record Identifier
- 9985224415102771
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