Journal article
Impact of renin-angiotensin system inhibitors on mortality during the COVID Pandemic among STEMI patients undergoing mechanical reperfusion: Insight from an international STEMI registry
Biomedicine & pharmacotherapy, Vol.138, pp.111469-111469
06/01/2021
DOI: 10.1016/j.biopha.2021.111469
PMCID: PMC7962982
PMID: 33740523
Abstract
Concerns have been raised on a potential interaction between renin-angiotensin system inhibitors (RASI) and the susceptibility to coronavirus disease 2019 (COVID-19). No data have been so far reported on the prognostic impact of RASI in patients suffering from ST-elevation myocardial infarction (STEMI) during COVID-19 pandemic, which was the aim of the present study.
STEMI patients treated with primary percutaneous coronary intervention (PPCI) and enrolled in the ISACS-STEMI COVID-19 registry were included in the present sub-analysis and divided according to RASI therapy at admission.
Our population is represented by 6095 patients, of whom 3654 admitted in 2019 and 2441 in 2020. No difference in the prevalence of SARSCoV2 infection was observed according to RASI therapy at admission (2.5% vs 2.1%, p = 0.5), which was associated with a significantly lower mortality (adjusted OR [95% CI]=0.68 [0.51–0.90], P = 0.006), confirmed in the analysis restricted to 2020 (adjusted OR [95% CI]=0.5[0.33–0.74], P = 0.001). Among the 5388 patients in whom data on in-hospital medication were available, in-hospital RASI therapy was associated with a significantly lower mortality (2.1% vs 16.7%, OR [95% CI]=0.11 [0.084–0.14], p < 0.0001), confirmed after adjustment in both periods. Among the 62 SARSCoV-2 positive patients, RASI therapy, both at admission or in-hospital, showed no prognostic effect.
This is the first study to investigate the impact of RASI therapy on the prognosis and SARSCoV2 infection of STEMI patients undergoing PPCI during the COVID-19 pandemic. Both pre-admission and in-hospital RASI were associated with lower mortality. Among SARSCoV2-positive patients, both chronic and in-hospital RASI therapy showed no impact on survival.
Details
- Title: Subtitle
- Impact of renin-angiotensin system inhibitors on mortality during the COVID Pandemic among STEMI patients undergoing mechanical reperfusion: Insight from an international STEMI registry
- Creators
- Giuseppe De Luca - Azienda Ospedaliero Universitaria Maggiore della CaritaMiha Cercek - Ljubljana University Medical CentreLisette Okkels Jensen - Odense University HospitalOliver Bushljetikj - Saints Cyril and Methodius University of SkopjeLucian Calmac - Clinical Emergency Hospital BucharestTom Johnson - University of BristolMontserrat Gracida Blancas - Interventional Cardiology Unit, Heart Disease Institute, Hospital Universitari de Bellvitge, SpainVladimir Ganyukov - Kemerovo State UniversityWojtek Wojakowski - Medical University of SilesiaClemens von Birgelen - Medisch Spectrum TwenteAlexander IJsselmuiden - Amphia ZiekenhuisBernardo Tuccillo - Division of Cardiology, Ospedale del Mare, Napoli, ItalyFrancesco Versaci - Ospedale Santa Maria GorettiJurrien Ten Berg - Division of Cardiology, St Antonius Hospital, Nieuwegein, The NetherlandsMika Laine - Helsinki University HospitalTim Berkout - Northwest HospitalGianni Casella - Ospedale MaggiorePetr Kala - Masaryk UniversityBernabé López Ledesma - H. Universitario y Politécnico La Fe, Valencia, SpainVictor Becerra - Hospital Clínico Universitario Virgen de la VictoriaRoberto Padalino - Division of Cardiology, Clinica Villa dei Fiori, Acerra, ItalyAndrea Santucci - Ospedale Santa MariaXavier Carrillo - Hospital Germans Triasi Pujol, Badalona, SpainAlessandra Scoccia - Division of Cardiology, Ospedale “Sant’Anna”, Ferrara, ItalyGiovanni AmorosoArpad Lux - Maastricht UniversityTomas Kovarnik - University Hospital Prague, Czech RepublicPeriklis Davlouros - Invasive Cardiology and Congenital Heart Disease, Patras University Hospital, Patras, GreeceGabriele Gabrielli - Interventional Cardiology Unit, Azienda Ospedaliero Universitaria “Ospedali Riuniti”, Ancona, ItalyXacobe Flores Rios - Complexo Hospetaliero Universitario La Coruna, La Coruna, SpainNikola Bakraceski - Center for Cardiovascular Diseases, Ohrid, North MacedoniaSébastien Levesque - Center Hospitalier Universitaire de Poitiers, Poitiers, University Hospital, Poitiers, FranceVincenzo Guiducci - AUSL-IRCCS Reggio Emilia, ItalyMichał Kidawa - Medical University of LodzLucia Marinucci - Clinical Emergency Hospital BucharestFilippo Zilio - Ospedale Santa ChiaraGennaro Galasso - Division of Cardiology, Ospedale San Giovanni di Dio e Ruggi d'Aragona, Salerno, ItalyEnrico Fabris - Azienda Ospedaliero Universitaria Ospedali RiunitiMaurizio Menichelli - Division of Cardiology, Ospedale “F. Spaziani“, Frosinone, ItalyStephane Manzo - Assistance Publique – Hôpitaux de ParisGianluca Caiazzo - Division of Cardiology, Ospedale “G Moscati”, Aversa, ItalyJose Moreu - Complejo Hospitalario Universitario de ToledoJuan Sanchis Forés - Hospital Clínico Universitario de ValenciaLuca Donazzan - Azienda Ospedaliero Universitaria Maggiore della CaritaLuigi Vignali - Interventional Cardiology Unit, Azienda Ospedaliera Sanitaria, Parma, ItalyRui Teles - Hospital de Santa CruzPierfrancesco Agostoni - Division of Cardiology, Ziekenhuis Netwerk Antwerpen (ZNA) Middelheim, Antwerp, BelgiumFrancisco Bosa Ojeda - Hospital Universitario de CanariasHeidi Lehtola - Oulu University HospitalSantiago Camacho-Freiere - Division of Cardiology, Juan Ramon Jimenez Hospital, Huelva, SpainAdriaan Kraaijeveld - University Medical Center UtrechtYlitalo Antti - Division of Cardiology, Heart Centre Turku, FinlandGabriella Visconti - Ospedale Santa MariaIñigo Lozano Martínez-Luengas - Division of Cardiology, Hospital Cabueñes, Gijon, SpainBruno Scheller - Division of Cardiology, Clinical and Experimental Interventional Cardiology, University of Saarland, GermanyDimitrios Alexopulos - Division of Cardiology, Attikon University Hospital, Athens, GreeceRaul Moreno - Division of Cardiology, Hospital la Paz, Madrid, SpainElvin Kedhi - Division of Cardiology, St-Jan Hospital, Brugge, BelgiumGiuseppe Uccello - Azienda Ospedaliero Universitaria Maggiore della CaritaBenjamin Faurie - Division of Cardiology, Groupe Hospitalier Mutualiste de Grenoble, FranceAlejandro Gutierrez Barrios - Division of Cardiology, Hospital Puerta del Mar, Cadiz, SpainFortunato Scotto Di Uccio - Division of Cardiology, Ospedale del Mare, Napoli, ItalyBor Wilbert - Division of Cardiology, St Antonius Hospital, Nieuwegein, The NetherlandsGiuliana Cortese - Department of Statistical Sciences, University of Padova, ItalyMaurits T. Dirksen - Division of Cardiology, Northwest Clinics Alkmaar, The NetherlandsGuido Parodi - Azienda Ospedaliero-Universitaria Sassari, ItalyMonica Verdoia - Ospedale degli Infermi
- Resource Type
- Journal article
- Publication Details
- Biomedicine & pharmacotherapy, Vol.138, pp.111469-111469
- Publisher
- Elsevier Masson SAS
- DOI
- 10.1016/j.biopha.2021.111469
- PMID
- 33740523
- PMCID
- PMC7962982
- ISSN
- 0753-3322
- eISSN
- 1950-6007
- Language
- English
- Date published
- 06/01/2021
- Academic Unit
- Electrical and Computer Engineering
- Record Identifier
- 9984627340502771
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