Journal article
Impact of right ventricular impairment on morbidity and mortality in takotsubo syndrome-a meta-analysis of observational trials
Heart failure reviews, Vol.27(1), pp.263-270
01/2022
DOI: 10.1007/s10741-020-09981-5
PMID: 32468276
Abstract
The impact of right ventricular impairment (RVI) on the morbidity and mortality of patients with Takotsubo syndrome (TTS) is well-debated. We conducted a meta-analysis to evaluate the mortality and morbidity risk associated with RVI compared with those without RVI in patients with TTS. A comprehensive search was performed in PubMed and Embase from inception to April 19, 2019. Our primary outcome of interest was in-hospital and long-term mortality. Other outcomes of interest were acute heart failure, left ventricular systolic function, tricuspid and mitral regurgitation, and length of hospital stay (LOS). We are reporting our outcomes as a cumulative odds ratio (OR). After an initial search, 10 studies with 1210 subjects were included in the quantitative analysis. Mean follow-up was 31 months. The odds of in-hospital and long-term mortality in TTS patients with and without RVI were not significantly different (p = 0.13 and 0.40). In TTS patients without RVI, the odds of acute heart failure, and mitral and tricuspid regurgitation were significantly lower at an OR of 0.26 (p < 0.0001), 0.40 (p = 0.0001), and 0.52 (p = 0.02) respectively. TTS patients with RVI had significantly lower mean LVEF (34% vs 41%, p = 0.03) and numerically higher mean LOS (9.5 days vs 7.6 days, p = 0.52) compared with those without RVI. The presence of RVI represents a severe form of TTS disease spectrum, characterized by severely reduced LVEF, higher incidence of MR and presence of TR. Although there was a trend toward increased in-hospital and long-term mortality, RVI in TTS does not portend worse survival.
Details
- Title: Subtitle
- Impact of right ventricular impairment on morbidity and mortality in takotsubo syndrome-a meta-analysis of observational trials
- Creators
- Suchith Shetty - Roy J. and Lucille A. Carver College of MedicineAaqib H Malik - Westchester Medical CenterManju Bengaluru Jayanna - Lankenau Institute for Medical ResearchWilbert S Aronow - Westchester Medical CenterAlexandros Briasoulis - University of IowaKan Liu - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Heart failure reviews, Vol.27(1), pp.263-270
- DOI
- 10.1007/s10741-020-09981-5
- PMID
- 32468276
- ISSN
- 1382-4147
- eISSN
- 1573-7322
- Language
- English
- Date published
- 01/2022
- Academic Unit
- Radiology; Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984318814402771
Metrics
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