Impact of sepsis on CD4 T cell immunity

Javier Cabrera-Perez; Stephanie A Condotta; Vladimir P Badovinac; Thomas S Griffith

doi:10.1189/jlb.5MR0114-067R

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Journal article

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Peer reviewed

Impact of sepsis on CD4 T cell immunity

Javier Cabrera-Perez, Stephanie A Condotta, Vladimir P Badovinac and Thomas S Griffith

Journal of leukocyte biology, Vol.96(5), pp.767-777

11/2014

DOI: 10.1189/jlb.5MR0114-067R

PMCID: PMC4197564

PMID: 24791959

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Abstract

Sepsis remains the primary cause of death from infection in hospital patients, despite improvements in antibiotics and intensive-care practices. Patients who survive severe sepsis can display suppressed immune function, often manifested as an increased susceptibility to (and mortality from) nosocomial infections. Not only is there a significant reduction in the number of various immune cell populations during sepsis, but there is also decreased function in the remaining lymphocytes. Within the immune system, CD4 T cells are important players in the proper development of numerous cellular and humoral immune responses. Despite sufficient clinical evidence of CD4 T cell loss in septic patients of all ages, the impact of sepsis on CD4 T cell responses is not well understood. Recent findings suggest that CD4 T cell impairment is a multipronged problem that results from initial sepsis-induced cell loss. However, the subsequent lymphopenia-induced numerical recovery of the CD4 T cell compartment leads to intrinsic alterations in phenotype and effector function, reduced repertoire diversity, changes in the composition of naive antigen-specific CD4 T cell pools, and changes in the representation of different CD4 T cell subpopulations (e.g., increases in Treg frequency). This review focuses on sepsis-induced alterations within the CD4 T cell compartment that influence the ability of the immune system to control secondary heterologous infections. The understanding of how sepsis affects CD4 T cells through their numerical loss and recovery, as well as function, is important in the development of future treatments designed to restore CD4 T cells to their presepsis state.

T-Lymphocyte Subsets - immunology

T-Lymphocytes, Regulatory - metabolism

Sepsis - immunology

Cytokines - metabolism

Humans

CD4-Positive T-Lymphocytes - metabolism

T-Lymphocytes, Regulatory - immunology

CD4-Positive T-Lymphocytes - immunology

Phenotype

Animals

Apoptosis - immunology

Sepsis - metabolism

T-Lymphocyte Subsets - metabolism

Details

Title: Subtitle: Impact of sepsis on CD4 T cell immunity
Creators: Javier Cabrera-Perez - Microbiology, Immunology, and Cancer Biology Graduate Program Medical Scientist Training Program
Stephanie A Condotta - Department of Pathology and
Vladimir P Badovinac - Department of Pathology and Interdisciplinary Program in Immunology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
Thomas S Griffith - Microbiology, Immunology, and Cancer Biology Graduate Program Center for Immunology, and Department of Urology, University of Minnesota Medical School, Minneapolis, Minnesota, USA; Minneapolis Veterans Administration Health Care System, Minneapolis, Minnesota, USA; and tgriffit@umn.edu
Resource Type: Journal article
Publication Details: Journal of leukocyte biology, Vol.96(5), pp.767-777
DOI: 10.1189/jlb.5MR0114-067R
PMID: 24791959
PMCID: PMC4197564
NLM abbreviation: J Leukoc Biol
ISSN: 0741-5400
eISSN: 1938-3673
Publisher: United States
Grant note: P30 CA077598 / NCI NIH HHS AI83286 / NIAID NIH HHS I01 BX001324 / BLRD VA R01 AI083286 / NIAID NIH HHS T32 GM008244 / NIGMS NIH HHS T32 AI007313 / NIAID NIH HHS
Language: English
Date published: 11/2014
Academic Unit: Microbiology and Immunology; Pathology
Record Identifier: 9984047888702771

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