Impact of stereotactic radiotherapy for craniopharyngioma: a large, academic hospital cohort

Geovanne Pedro Mauro; Leila Maria Da Róz; Vinicius de Carvalho Gico; Eduardo Weltman; Evandro César de Souza; Rosangela Correa Villar; Hamilton Matushita; Carlos Gilberto Carlotti

doi:10.1007/s00381-024-06686-0

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Impact of stereotactic radiotherapy for craniopharyngioma: a large, academic hospital cohort

Journal article

Peer reviewed

Impact of stereotactic radiotherapy for craniopharyngioma: a large, academic hospital cohort

Geovanne Pedro Mauro, Leila Maria Da Róz, Vinicius de Carvalho Gico, Eduardo Weltman, Evandro César de Souza, Rosangela Correa Villar, Hamilton Matushita and Carlos Gilberto Carlotti

Child's nervous system, Vol.41(1), p.11

12/01/2025

DOI: 10.1007/s00381-024-06686-0

PMID: 39607561

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Abstract

Adjuvant radiotherapy has been a standard of care for craniopharyngioma. Nevertheless, it is a rare disease with multiple presentations, and results with conservative surgery followed by radiotherapy (RT) can vary. We compared treatment results for both adult and pediatric patients. This is a retrospective cohort of patients treated between 2010 and 2023 in a single university hospital. Seventy-nine patients' clinical data was assessed. Median follow-up was 75.5 months (7.1-210.2 months). Median age was 24.4 years, and 40 (50.6%) were considered pediatric patients. Median lesion size after surgery was 3.4 cm (range 0.4 to 10.4 cm). Ten patients (16.9%) were submitted to Ommaya reservoir placement surgery, and most (70%) have lesion reductions that impact radiotherapy planning. Timing of radiotherapy whether adjuvant or salvage did not impact progression-free survival (PFS) (p = 0.39). Median PFS was not reached, and mean PFS was 65.7 months. Disease control was obtained in 67 (84.1%) patients. We achieved great results with consisting institutional protocol in both adult and childhood craniopharyngioma. Timing of RT did not translate into loss of disease control in our study, with good results for salvage radiotherapy. Ommaya reservoirs can impact RT planning, but not outcomes.

Adolescent

Adult

Aged

Child

Child, Preschool

Cohort Studies

Craniopharyngioma - radiotherapy

Craniopharyngioma - surgery

Female

Humans

Male

Middle Aged

Pituitary Neoplasms - radiotherapy

Pituitary Neoplasms - surgery

Radiosurgery - methods

Retrospective Studies

Treatment Outcome

Young Adult

Details

Title: Subtitle: Impact of stereotactic radiotherapy for craniopharyngioma: a large, academic hospital cohort
Creators: Geovanne Pedro Mauro - Universidade de São Paulo
Leila Maria Da Róz - Universidade de São Paulo
Vinicius de Carvalho Gico - Instituto do Câncer do Estado de São Paulo
Eduardo Weltman - Universidade de São Paulo
Evandro César de Souza - Universidade de São Paulo
Rosangela Correa Villar - Universidade de São Paulo
Hamilton Matushita - Universidade de São Paulo
Carlos Gilberto Carlotti - Universidade de São Paulo
Resource Type: Journal article
Publication Details: Child's nervous system, Vol.41(1), p.11
DOI: 10.1007/s00381-024-06686-0
PMID: 39607561
NLM abbreviation: Childs Nerv Syst
ISSN: 0256-7040
eISSN: 1433-0350
Language: English
Date published: 12/01/2025
Academic Unit: Radiation Oncology
Record Identifier: 9984914147102771

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