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Impact of stress on cancer metastasis
Journal article   Open access   Peer reviewed

Impact of stress on cancer metastasis

Myrthala Moreno-Smith, Susan K Lutgendorf and Anil K Sood
Future oncology (London, England), Vol.6(12), pp.1863-1881
12/2010
DOI: 10.2217/fon.10.142
PMCID: PMC3037818
PMID: 21142861
url
https://www.ncbi.nlm.nih.gov/pmc/articles/3037818View
Open Access

Abstract

The influence of psychosocial factors on the development and progression of cancer has been a longstanding hypothesis since ancient times. In fact, epidemiological and clinical studies over the past 30 years have provided strong evidence for links between chronic stress, depression and social isolation and cancer progression. By contrast, there is only limited evidence for the role of these behavioral factors in cancer initiation. Recent cellular and molecular studies have identified specific signaling pathways that impact cancer growth and metastasis. This article provides an overview of the relationship between psychosocial factors, specifically chronic stress, and cancer progression.
signaling pathway stress cancer catecholamine metastasis

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