Journal article
Impact of the Swank and Wahls elimination dietary interventions on fatigue and quality of life in relapsing-remitting multiple sclerosis: The WAVES randomized parallel-arm clinical trial
Multiple sclerosis journal - experimental, translational and clinical, Vol.7(3), pp.20552173211035399-20552173211035399
07/01/2021
DOI: 10.1177/20552173211035399
PMCID: PMC8326636
PMID: 34377527
Abstract
ObjectiveTo compare the effect of the modified Paleolithic elimination (Wahls) and low-saturated fat (Swank) diets in relapsing-remitting MS (RRMS). MethodsIndividuals (n = 87) with RRMS were randomized to the Swank or Wahls diets in a parallel group clinical trial consisting of four timepoints: 1) run-in, 2) baseline, 3) 12-weeks, and 4) 24-weeks. Results77 participants completed 12 weeks and 72 completed 24 weeks. The 12-week change from baseline in fatigue was -0.94 ± 0.18 (FSS) and -9.87 ± 1.93 (MFIS; both p < 0.0001) for Swank, and -0.71 ± 0.24 (FSS; p = 0.004) and -14.41 ± 2.22 (MFIS; p ≤ 0.0001) for Wahls. Physical MSQoL scores improved by 6.04 ± 2.18 (p = 0.006) for Swank and by 14.5 ± 2.63 (p < 0.0001) for Wahls. Mental MSQoL scores improved by 11.3 ± at 2.79 (p < 0.0001) for Wahls while the Swank did not change (3.85 ± 2.63; p = 0.14). Neither group showed significant changes in 6-minute walking distance at 12 weeks. All outcomes were maintained or further improved at 24 weeks. ConclusionsBoth diets were associated with clinically meaningful within-group reductions in fatigue and improvements in QoL.Trial Registration: Clinicaltrials.gov Identifier: NCT02914964.
Details
- Title: Subtitle
- Impact of the Swank and Wahls elimination dietary interventions on fatigue and quality of life in relapsing-remitting multiple sclerosis: The WAVES randomized parallel-arm clinical trial
- Creators
- Terry L Wahls - Department of Internal Medicine, University of IowaTyler J Titcomb - Department of Internal Medicine, University of IowaBabita Bisht - Department of Internal Medicine, University of IowaPatrick Ten Eyck - Institute for Clinical and Translational Science, University of IowaLinda M Rubenstein - Department of Epidemiology, University of IowaLucas J CarrWarren G Darling - Department of Health and Human Physiology, University of IowaKarin F Hoth - Department of Psychiatry, University of IowaJohn Kamholz - Department of Neurology, University of IowaLinda G Snetselaar
- Resource Type
- Journal article
- Publication Details
- Multiple sclerosis journal - experimental, translational and clinical, Vol.7(3), pp.20552173211035399-20552173211035399
- DOI
- 10.1177/20552173211035399
- PMID
- 34377527
- PMCID
- PMC8326636
- ISSN
- 2055-2173
- eISSN
- 2055-2173
- Language
- English
- Date published
- 07/01/2021
- Academic Unit
- Neurology; Psychiatry; Epidemiology; Iowa Neuroscience Institute; Biostatistics; Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center; General Internal Medicine; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984120580002771
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