Impact of the immune profiles of hypertensive patients with and without obesity on COVID-19 severity

Renata Moll-Bernardes; Juliana R Ferreira; Andréa Silvestre Sousa; Mariana B Tortelly; Adriana L Pimentel; Ana Cristina B S Figueiredo; Eduardo B Schaustz; José Carlos Pizzolante Secco; Allan Robson Kluser Sales; Flavia V O Terzi; Adriana Xavier de Brito; Renée O Sarmento; Marcia M Noya-Rabelo; Sergio Fortier; Flavia A Matos E Silva; Narendra Vera; Luciana Conde; Mauro Jorge Cabral-Castro; Denilson C Albuquerque; Paulo Rosado de-Castro; Gabriel C Camargo; Martha V T Pinheiro; Olga F Souza; Fernando A Bozza; Ronir R Luiz; Emiliano Medei

doi:10.1038/s41366-023-01407-0

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Impact of the immune profiles of hypertensive patients with and without obesity on COVID-19 severity

Journal article

Peer reviewed

Impact of the immune profiles of hypertensive patients with and without obesity on COVID-19 severity

Renata Moll-Bernardes, Juliana R Ferreira, Andréa Silvestre Sousa, Mariana B Tortelly, Adriana L Pimentel, Ana Cristina B S Figueiredo, Eduardo B Schaustz, José Carlos Pizzolante Secco, Allan Robson Kluser Sales, Flavia V O Terzi, …

International journal of obesity (2005), Vol.48(2), pp.254-262

02/01/2024

DOI: 10.1038/s41366-023-01407-0

PMID: 37932408

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Abstract

Comorbidities such as obesity, hypertension, and diabetes are associated with COVID-19 development and severity, probably due to immune dysregulation; however, the mechanisms underlying these associations are not clear. The immune signatures of hypertensive patients with obesity with COVID-19 may provide new insight into the mechanisms of immune dysregulation and progression to severe disease in these patients. Hypertensive patients were selected prospectively from a multicenter registry of adults hospitalized with COVID-19 and stratified according to obesity (BMI ≥ 30 kg/m²). Clinical data including baseline characteristics, complications, treatment, and 46 immune markers were compared between groups. Logistic regression was performed to identify variables associated with the risk of COVID-19 progression in each group. The sample comprised 213 patients (89 with and 124 without obesity). The clinical profiles of patients with and without obesity differed, suggesting potential interactions with COVID-19 severity. Relative to patients without obesity, patients with obesity were younger and fewer had cardiac disease and myocardial injury. Patients with obesity had higher EGF, GCSF, GMCSF, interleukin (IL)-1ra, IL-5, IL-7, IL-8, IL-15, IL-1β, MCP 1, and VEGF levels, total lymphocyte counts, and CD8 CD38 mean fluorescence intensity (MFI), and lower NK-NKG2A MFI and percentage of CD8 CD38 T cells. Significant correlations between cytokine and immune cell expression were observed in both groups. Five variables best predicted progression to severe COVID-19 in patients with obesity: diabetes, the EGF, IL-10, and IL-13 levels, and the percentage of CD8 HLA-DR CD38 cells. Three variables were predictive for patients without obesity: myocardial injury and the percentages of B lymphocytes and HLA-DR CD38 cells. Our findings suggest that clinical and immune variables and obesity interact synergistically to increase the COVID-19 progression risk. The immune signatures of hypertensive patients with and without obesity severe COVID-19 highlight differences in immune dysregulation mechanisms, with potential therapeutic applications.

Adult

CD8-Positive T-Lymphocytes

COVID-19 - complications

COVID-19 - metabolism

Diabetes Mellitus

Epidermal Growth Factor - metabolism

HLA-DR Antigens - metabolism

Humans

Hypertension - complications

Hypertension - epidemiology

Hypertension - metabolism

Obesity - complications

Obesity - metabolism

Vascular Endothelial Growth Factor A

Details

Title: Subtitle: Impact of the immune profiles of hypertensive patients with and without obesity on COVID-19 severity
Creators: Renata Moll-Bernardes - D’Or Institute for Research and Education
Juliana R Ferreira - D’Or Institute for Research and Education
Andréa Silvestre Sousa - D’Or Institute for Research and Education
Mariana B Tortelly - D’Or Institute for Research and Education
Adriana L Pimentel - D’Or Institute for Research and Education
Ana Cristina B S Figueiredo - D’Or Institute for Research and Education
Eduardo B Schaustz - D’Or Institute for Research and Education
José Carlos Pizzolante Secco - D’Or Institute for Research and Education
Allan Robson Kluser Sales - D’Or Institute for Research and Education
Flavia V O Terzi - D’Or Institute for Research and Education
Adriana Xavier de Brito - D’Or Institute for Research and Education
Renée O Sarmento - D’Or Institute for Research and Education
Marcia M Noya-Rabelo - D’Or Institute for Research and Education
Sergio Fortier - D’Or Institute for Research and Education
Flavia A Matos E Silva - D’Or Institute for Research and Education
Narendra Vera - Universidade Federal do Rio de Janeiro
Luciana Conde - Escola Bahiana de Medicina e Saúde Pública
Mauro Jorge Cabral-Castro - Universidade Federal Fluminense
Denilson C Albuquerque - D’Or Institute for Research and Education
Paulo Rosado de-Castro - D’Or Institute for Research and Education
Gabriel C Camargo - D’Or Institute for Research and Education
Martha V T Pinheiro - D’Or Institute for Research and Education
Olga F Souza - D’Or Institute for Research and Education
Fernando A Bozza - Fundação Oswaldo Cruz
Ronir R Luiz - D’Or Institute for Research and Education
Emiliano Medei - D’Or Institute for Research and Education
Resource Type: Journal article
Publication Details: International journal of obesity (2005), Vol.48(2), pp.254-262
DOI: 10.1038/s41366-023-01407-0
PMID: 37932408
NLM abbreviation: Int J Obes (Lond)
ISSN: 0307-0565
eISSN: 1476-5497
Language: English
Date published: 02/01/2024
Academic Unit: Radiology
Record Identifier: 9985143553602771

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