Journal article
Impact of vitamin D supplementation on markers of inflammation in adults with cystic fibrosis hospitalized for a pulmonary exacerbation
European Journal of Clinical Nutrition, Vol.66(9), p.1072
09/01/2012
DOI: 10.1038/ejcn.2012.82
PMCID: PMC3638806
PMID: 22805498
Abstract
Patients with cystic fibrosis (CF) suffer from chronic lung infection and inflammation leading to respiratory failure. Vitamin D deficiency is common in patients with CF, and correction of vitamin D deficiency may improve innate immunity and reduce inflammation in patients with CF. We conducted a double-blinded, placebo-controlled, randomized clinical trial of high-dose vitamin D to assess the impact of vitamin D therapy on antimicrobial peptide concentrations and markers of inflammation. We randomized 30 adults with CF hospitalized with a pulmonary exacerbation to 250 000 IU of cholecalciferol or placebo, and evaluated changes in plasma concentrations of inflammatory markers and the antimicrobial peptide LL-37 at baseline and 12 weeks post intervention. In the vitamin D group, there was a 50.4% reduction in tumor necrosis factor-α (TNF-α) at 12 weeks (P<0.01), and there was a trend for a 64.5% reduction in interleukin-6 (IL-6) (P=0.09). There were no significant changes in IL-1β, IL-8, IL-10, IL-18BP and NGAL (neutrophil gelatinase-associated lipocalin). We conclude that a large bolus dose of vitamin D is associated with reductions in two inflammatory cytokines, IL-6 and TNF-α. This study supports the concept that vitamin D may help regulate inflammation in CF, and that further research is needed to elucidate the potential mechanisms involved and the impact on clinical outcomes.
Details
- Title: Subtitle
- Impact of vitamin D supplementation on markers of inflammation in adults with cystic fibrosis hospitalized for a pulmonary exacerbation
- Creators
- R.E Grossmann - University of Iowa, NursingS.M Zughaier - Emory University School of MedicineS Liu - Emory UniversityR.H LylesV Tangpricha - Emory University
- Resource Type
- Journal article
- Publication Details
- European Journal of Clinical Nutrition, Vol.66(9), p.1072
- DOI
- 10.1038/ejcn.2012.82
- PMID
- 22805498
- PMCID
- PMC3638806
- NLM abbreviation
- Eur J Clin Nutr
- ISSN
- 0954-3007
- eISSN
- 1476-5640
- Publisher
- Nature Publishing Group
- Copyright
- Copyright © 2012, Macmillan Publishers Limited
- Grant note
- This work was supported in part by the following grants: PHS Grant UL1 RR025008 from the Clinical and Translational Science Award program, National Institutes of Health, grant numbers TL1 RR025010 and K23AR054334, and the CF Foundation.
- Language
- English
- Date published
- 09/01/2012
- Description audience
- Professional; Academic
- Academic Unit
- Nursing
- Record Identifier
- 9983557101602771
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