Journal article
Impaired Bone Growth After Ileal Augmentation Cystoplasty
The Journal of urology, Vol.157(5), pp.1873-1879
05/01/1997
DOI: 10.1016/S0022-5347(01)64890-0
PMID: 9112552
Abstract
Purpose: We evaluated how ileal augmentation cystoplasty predisposes growing animals to hyperchloremic acidosis and abnormal skeletal development. Materials and Methods: Weanling female Wistar rats weighing 35 to 50 gm. underwent ileal augmentation cystoplasty or sham operation consisting of a similar ileal resection and closure (ileoileostomy). Both groups were stressed with l% ammonium chloride loading. Serial bone densitometry measurements, weight and blood gas studies were performed in an 8-week growth period. Femur bone ashing and mineral analysis, arterial blood gas studies and serum bone mineral determinations (calcium, magnesium and phosphorus) were obtained at study conclusion. Results: Augmented and control animals had similar serum calcium, phosphorus and magnesium concentrations. In augmented animals metabolic acidosis developed with respiratory compensation and decreased mean serum bicarbonate plus or minus standard deviation compared to controls (18.34 ± 3.23 versus 21.76 ± 2.46 mEq./1., p <0.003). Growth curves of both groups were similar, although augmented animals had shorter femur lengths than controls (p <0.04). Bone density results were mixed. Whole body bone density was decreased (p [removed]
Details
- Title: Subtitle
- Impaired Bone Growth After Ileal Augmentation Cystoplasty
- Creators
- Jerald A. Hochstetler - University of IowaMichael J. Flanigan - University of IowaKarl J. Kreder - University of Iowa
- Resource Type
- Journal article
- Publication Details
- The Journal of urology, Vol.157(5), pp.1873-1879
- DOI
- 10.1016/S0022-5347(01)64890-0
- PMID
- 9112552
- ISSN
- 0022-5347
- eISSN
- 1527-3792
- Language
- English
- Date published
- 05/01/1997
- Academic Unit
- Obstetrics and Gynecology; Urology; Internal Medicine
- Record Identifier
- 9984383278002771
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