Journal article
Impaired Endothelial Function in Patients With Postural Tachycardia Syndrome
Hypertension (Dallas, Tex. 1979), Vol.77(3), pp.1001-1009
03/03/2021
DOI: 10.1161/HYPERTENSIONAHA.120.16238
PMCID: PMC7878337
PMID: 33486983
Abstract
The purpose of this study is to evaluate endothelial function in postural tachycardia syndrome (PoTS), a poorly understood chronic condition characterized by a state of consistent orthostatic tachycardia (delta heart rate >= 30 beats per minute) upon standing without orthostatic hypotension. Nineteen patients with PoTS and 9 healthy controls were studied after 3 days of a fixed, caffeine-free, normal sodium (150 milliequivalents/day) diet. All participants underwent autonomic function testing, including sinus arrhythmia, valsalva maneuver, hyperventilation, cold pressor, handgrip, and a standing test with catecholamine measurements, followed by endothelial function testing. We analyzed 3 measures of endothelial function: percent brachial flow-mediated dilation, digital pulsatile arterial tonometry, and postischemic percent leg blood flow. Flow-mediated dilation was significantly lower in patients with PoTS (6.23 +/- 3.54% for PoTS) than in healthy controls (10.6 +/- 4.37% for controls versus, P=0.014). PoTS and controls had similar digital pulsatile arterial tonometry (1.93 +/- 0.40 arbitrary units for controls versus 2.13 +/- 0.63 arbitrary units for PoTS). PoTS had similar but suggestive percent leg blood flow to controls (313 +/- 158% for PoTS versus 468 +/- 236% for controls, P=0.098). Patients with PoTS have significantly reduced flow-mediated dilation compared with healthy controls, suggesting that PoTS is characterized by endothelial dysfunction in conduit arteries.
Details
- Title: Subtitle
- Impaired Endothelial Function in Patients With Postural Tachycardia Syndrome
- Creators
- Abby H. Chopoorian - Vanderbilt University Medical CenterAmr Wahba - Vanderbilt University Medical CenterJorge Celedonio - Vanderbilt University Medical CenterVictor Nwazue - Vanderbilt University Medical CenterEmily C. Smith - Vanderbilt University Medical CenterEmily M. Garland - Vanderbilt University Medical CenterSachin Paranjape - Vanderbilt University Medical CenterLuis E. Okamoto - Vanderbilt University Medical CenterBonnie K. Black - Vanderbilt University Medical CenterItalo Biaggioni - Vanderbilt University Medical CenterSatish R. Raj - Libin Cardiovascular Institute of AlbertaAlfredo Gamboa - Vanderbilt University Medical Center
- Resource Type
- Journal article
- Publication Details
- Hypertension (Dallas, Tex. 1979), Vol.77(3), pp.1001-1009
- Publisher
- Lippincott Williams & Wilkins
- DOI
- 10.1161/HYPERTENSIONAHA.120.16238
- PMID
- 33486983
- PMCID
- PMC7878337
- ISSN
- 0194-911X
- eISSN
- 1524-4563
- Number of pages
- 9
- Grant note
- UL1 TR000445 / National Institutes of Health (NIH); United States Department of Health & Human Services; National Institutes of Health (NIH) - USA
- Language
- English
- Date published
- 03/03/2021
- Academic Unit
- Internal Medicine
- Record Identifier
- 9984702824802771
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