Journal article
Impaired Overnight Counterregulatory Hormone Responses to Spontaneous Hypoglycemia in Children with Type 1 Diabetes
Pediatric diabetes, Vol.8(4), pp.199-205
08/2007
DOI: 10.1111/j.1399-5448.2007.00248.x
PMCID: PMC1986771
PMID: 17659061
Abstract
To assess the changes in counterregulatory hormones overnight after an afternoon of structured exercise or sedentary activity in children with Type 1 Diabetes Mellitus (T1DM), the Diabetes Research in Children Network (DirecNet) studied 50 children (10-<18y) with T1DM in 5 clinical research centers on two separate days (with and without an afternoon exercise session) using a crossover design. Glucose, epinephrine, norepinephrine, cortisol, growth hormone (GH) and glucagon concentrations were measured hourly overnight. Nocturnal hypoglycemia (plasma glucose concentrations ≤70 mg/dL [3.9 mmol/L]) occurred more frequently on the nights following exercise (56% vs. 36%; p=0.008). Mean hourly concentrations of most hormones did not differ between sedentary or exercise nights or between nights with or without hypoglycemia. Spontaneous nocturnal hypoglycemia only stimulated small increases in plasma epinephrine and growth hormone concentrations and failed to cause a rise in norepinephrine, cortisol or glucagon levels in comparison to values during the hour before or after hypoglycemia or other times during those same nights. Counterregulatory hormone responses to spontaneous nocturnal hypoglycemia were markedly decreased regardless of whether there was antecedent afternoon exercise in children with T1DM. Sleep-induced impairments in counterregulatory hormone responses likely contribute to the increased risk of hypoglycemia during the entire overnight period in youth with T1DM.
Details
- Title: Subtitle
- Impaired Overnight Counterregulatory Hormone Responses to Spontaneous Hypoglycemia in Children with Type 1 Diabetes
- Creators
- Diabetes Research in Children Network (DirecNet) Study Group
- Contributors
- Eva Tsalikian (Contributor) - University of Iowa, Stead Family Department of Pediatrics
- Resource Type
- Journal article
- Publication Details
- Pediatric diabetes, Vol.8(4), pp.199-205
- DOI
- 10.1111/j.1399-5448.2007.00248.x
- PMID
- 17659061
- PMCID
- PMC1986771
- ISSN
- 1399-543X
- eISSN
- 1399-5448
- Language
- English
- Date published
- 08/2007
- Academic Unit
- Stead Family Department of Pediatrics
- Record Identifier
- 9984093501902771
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