Journal article
Impaired dilatation of cerebral arterioles in chronic hypertension
Blood vessels, Vol.27(2-5), pp.258-262
1990
DOI: 10.1159/000158817
PMID: 2242446
Abstract
Several mechanisms impair cerebral vasodilatation during chronic hypertension. First, the external diameter of cerebral arterioles is reduced during chronic hypertension by structural 'remodeling'. Thus, both vascular hypertrophy and remodeling result in encroachment on the lumen. Second, endothelium-dependent dilatation of cerebral vessels is impaired during chronic hypertension. Third, blood flow through cerebral collaterals is impaired by chronic hypertension, so that an important compensatory mechanism is compromised. Impaired vasodilator responses, together with limitation of increases in collateral blood flow, may predispose to cerebral ischemia and stroke during chronic hypertension.
Details
- Title: Subtitle
- Impaired dilatation of cerebral arterioles in chronic hypertension
- Creators
- Donald D Heistad - Department of Internal Medicine, Veterans Administration Medical Center, Iowa City, IowaWilliam G MayhanPeter CoyleGary L Baumbach
- Resource Type
- Journal article
- Publication Details
- Blood vessels, Vol.27(2-5), pp.258-262
- DOI
- 10.1159/000158817
- PMID
- 2242446
- NLM abbreviation
- Blood Vessels
- ISSN
- 0303-6847
- Publisher
- Switzerland
- Grant note
- NS 24621 / NINDS NIH HHS HL 14230 / NHLBI NIH HHS HL 16066 / NHLBI NIH HHS
- Language
- English
- Date published
- 1990
- Academic Unit
- Pathology; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040332802771
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