Impaired motor performance and learning in glia maturation factor-knockout mice

Ramon Lim; Asgar Zaheer; Houdy Khosravi; John H Freeman Jr; Hunter E Halverson; John A Wemmie; Baoli Yang

doi:10.1016/j.brainres.2004.08.003

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Impaired motor performance and learning in glia maturation factor-knockout mice

Journal article

Peer reviewed

Impaired motor performance and learning in glia maturation factor-knockout mice

Ramon Lim, Asgar Zaheer, Houdy Khosravi, John H Freeman Jr, Hunter E Halverson, John A Wemmie and Baoli Yang

Brain research, Vol.1024(1-2), pp.225-232

10/22/2004

DOI: 10.1016/j.brainres.2004.08.003

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Abstract

Glia maturation factor (GMF) is a unique brain protein localized in astrocytes and some neuronal populations. Studies with overexpression of GMF using adenovirus vector have uncovered its regulatory role in intracellular signal transduction and downstream induction of biologically active molecules, including the neurotrophins and cytokines. The current paper deals with the behavior of mice devoid of GMF protein (knockout). GMF-null mice developed normally without gross abnormality. When tested for simple position discrimination using a T-maze and for spatial memory using a Morris water maze, the knockout mice performed as well as the wild-type, showing no defect in maze learning. However, with beam walking, GMF-knockout mice performed poorly and failed to learn. Knockout mice were also defective in learning the eyeblink classical conditioning. Histologically, the knockout mice showed a loss of neurons in the inferior olive, which is a component of the circuitry of eyeblink conditioning, and is also essential for motor performance. The structural abnormality in GMF-null mice explained their impaired ability for both motor performance and motor learning.

Obstetrics and Gynecology

Details

Title: Subtitle: Impaired motor performance and learning in glia maturation factor-knockout mice
Creators: Ramon Lim
Asgar Zaheer
Houdy Khosravi
John H Freeman Jr - University of Iowa, Psychological and Brain Sciences
Hunter E Halverson
John A Wemmie
Baoli Yang - University of Iowa
Resource Type: Journal article
Publication Details: Brain research, Vol.1024(1-2), pp.225-232
DOI: 10.1016/j.brainres.2004.08.003
NLM abbreviation: Brain Res
ISSN: 0006-8993
Language: English
Date published: 10/22/2004
Academic Unit: Iowa Neuroscience Institute; BioVentures Center; Obstetrics and Gynecology
Record Identifier: 9983557242802771

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