Journal article
Impaired sensory processing measured by functional MRI in Bipolar disorder manic and depressed mood states
Brain imaging and behavior, Vol.12(3), pp.837-847
06/2018
DOI: 10.1007/s11682-017-9741-8
PMCID: PMC5752628
PMID: 28674759
Abstract
Bipolar disorder is characterized by recurring episodes of depression and mania. Defining differences in brain function during these states is an important goal of bipolar disorder research. However, few imaging studies have directly compared brain activity between bipolar mood states. Herein, we compare functional magnetic resonance imaging (fMRI) responses during a flashing checkerboard stimulus between bipolar participants across mood states (euthymia, depression, and mania) in order to identify functional differences between these states. 40 participants with bipolar I disorder and 33 healthy controls underwent fMRI during the presentation of the stimulus. A total of 23 euthymic-state, 16 manic-state, 15 depressed-state, and 32 healthy control imaging sessions were analyzed in order to compare functional activation during the stimulus between mood states and with healthy controls. A reduced response was identified in the visual cortex in both the depressed and manic groups compared to euthymic and healthy participants. Functional differences between bipolar mood states were also observed in the cerebellum, thalamus, striatum, and hippocampus. Functional differences between mood states occurred in several brain regions involved in visual and other sensory processing. These differences suggest that altered visual processing may be a feature of mood states in bipolar disorder. The key limitations of this study are modest mood-state group size and the limited temporal resolution of fMRI which prevents the segregation of primary visual activity from regulatory feedback mechanisms.
Details
- Title: Subtitle
- Impaired sensory processing measured by functional MRI in Bipolar disorder manic and depressed mood states
- Creators
- Joseph J Shaffer Jr - , PBDB L420, 169 Newton Rd., Iowa City, IA, 52242, USA. joseph-shaffer@uiowa.eduCasey P Johnson - Department of Radiology, University of Iowa, Iowa City, IA, USAJess G Fiedorowicz - Abboud Cardiovascular Research Center, University of Iowa, Iowa City, IA, USAGary E Christensen - Department of Radiation Oncology, University of Iowa, Iowa City, IA, USAJohn A Wemmie - Pappajohn Biomedical Institute, University of Iowa, Iowa City, IA, USAVincent A Magnotta - Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA
- Resource Type
- Journal article
- Publication Details
- Brain imaging and behavior, Vol.12(3), pp.837-847
- DOI
- 10.1007/s11682-017-9741-8
- PMID
- 28674759
- PMCID
- PMC5752628
- NLM abbreviation
- Brain Imaging Behav
- ISSN
- 1931-7557
- eISSN
- 1931-7565
- Publisher
- United States
- Grant note
- T32 NS045549 / NINDS NIH HHS R01 MH111578 / NIMH NIH HHS Independent Investigator / National Alliance for Research on Schizophrenia and Depression 5R01MH085724 / NIMH NIH HHS K23 MH083695 / NIMH NIH HHS I01 BX000741 / BLRD VA Independent Investigator Award / National Alliance for Research on Schizophrenia and Depression Young Investigator / National Alliance for Research on Schizophrenia and Depression Merit Award / U.S. Department of Veterans Affairs R01 MH085724 / NIMH NIH HHS P01HL014388 / NHLBI NIH HHS Private Donation / Roger Koch R01 HL113863 / NHLBI NIH HHS U54 TR001013 / NCATS NIH HHS P01 HL014388 / NHLBI NIH HHS K23MH083695 / NIMH NIH HHS U54TR001013 / University of Iowa Institute for Clinical and Translational Science R01HL113863 / NHLBI NIH HHS
- Language
- English
- Date published
- 06/2018
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Molecular Physiology and Biophysics; Psychiatry; Epidemiology; Iowa Neuroscience Institute; Radiation Oncology; Radiation Research Laboratory; Neurosurgery; Internal Medicine
- Record Identifier
- 9984003463202771
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