Journal article
Impaired skeletal muscle and skin microcirculatory function in human obesity
Journal of hypertension, Vol.20(7), pp.1401-1405
07/2002
DOI: 10.1097/00004872-200207000-00027
PMID: 12131537
Abstract
BACKGROUND Obesity is associated with exaggerated blood pressure and systemic vascular resistance responses to mental stress.
OBJECTIVE To test the hypothesis that skin and muscle microvascular dilatation in response to mental stress is blunted in obesity.
DESIGN AND METHODS Blood pressure, heart rate and forearm and skin blood flow responses to mental stress were compared in 23 obese and 23 age- and sex-matched lean normotensive individuals.
RESULTS Blood pressure was almost identical in both obese (mean 94 ± 1 mmHg) and lean (93 ± 2 mmHg) individuals. The increase in blood pressure during mental stress was similar in obese and lean individuals (2.0 ± 0.9% compared with 3.1 ± 4.0%;P = 0.8). Forearm vascular resistance decreased during mental stress in both groups, but this decrease was significantly blunted in obese individuals compared with controls (decreases of 14 ± 4% and 26 ± 3%;P < 0.01). Skin microcirculatory dilatation was also significantly blunted in obese individuals compared with controls (decreases of 5 ± 2 and 17 ± 4%;P = 0.02).
CONCLUSIONS Normotensive obese individuals exhibit markedly impaired muscle and skin microcirculatory responses to mental stress. The increased propensity of obese individuals to develop hypertension under conditions of chronic psychosocial stress may underlie obesity-related hypertension and cardiovascular disease.
Details
- Title: Subtitle
- Impaired skeletal muscle and skin microcirculatory function in human obesity
- Creators
- Alexei Agapitov - General Clinical Research Center and Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USAMarcelo CorreiaChristine SinkeyJohn DoppWilliam Haynes
- Resource Type
- Journal article
- Publication Details
- Journal of hypertension, Vol.20(7), pp.1401-1405
- Publisher
- Lippincott Williams & Wilkins, Inc
- DOI
- 10.1097/00004872-200207000-00027
- PMID
- 12131537
- ISSN
- 0263-6352
- eISSN
- 1473-5598
- Language
- English
- Date published
- 07/2002
- Academic Unit
- Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984094751702771
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