Impaired upper alpha synchronisation during working memory retention in depression and depression following traumatic brain injury

Neil W Bailey; Rebecca A Segrave; Kate E Hoy; Jerome J Maller; Paul B Fitzgerald

doi:10.1016/j.biopsycho.2014.03.008

Back

Impaired upper alpha synchronisation during working memory retention in depression and depression following traumatic brain injury

Journal article

Peer reviewed

Impaired upper alpha synchronisation during working memory retention in depression and depression following traumatic brain injury

Neil W Bailey, Rebecca A Segrave, Kate E Hoy, Jerome J Maller and Paul B Fitzgerald

Biological psychology, Vol.99(1), pp.115-124

05/01/2014

DOI: 10.1016/j.biopsycho.2014.03.008

PMID: 24686072

View Online

Abstract

Rates of major depressive disorder (MDD) following traumatic brain injury (TBI) are higher than in the general population. Individuals with depression following traumatic brain injury (TBI-MDD) exhibit working memory (WM) impairments. Electrophysiological evidence has suggested that parieto-occipital upper alpha synchronisation may enhance WM retention by inhibiting irrelevant processes. The current research assessed whether retention period WM parieto-occipital upper alpha activity is disrupted in groups with TBI-only (N=20), MDD (N=17), and TBI-MDD (N=15) compared to healthy controls (N=31). Behavioural data indicated poorer performance in MDD and TBI-MDD. Parietal-occipital upper alpha was reduced in the MDD and TBI-MDD groups, but was unaffected in TBI-only. These results suggest inhibitory deficits may account for WM impairments in MDD and TBI-MDD, and that for individuals with TBI-MDD it may be the depression rather than the TBI that impairs WM.

Adolescent

Adult

Alpha Rhythm - physiology

Brain Injuries - complications

Brain Mapping

Cerebral Cortex - physiopathology

Depression - complications

Depression - etiology

Female

Humans

Male

Memory Disorders - etiology

Memory, Short-Term - physiology

Middle Aged

Neuropsychological Tests

Psychiatric Status Rating Scales

Retention (Psychology) - physiology

Severity of Illness Index

Trauma Severity Indices

Young Adult

Details

Title: Subtitle: Impaired upper alpha synchronisation during working memory retention in depression and depression following traumatic brain injury
Creators: Neil W Bailey - The Alfred Hospital
Rebecca A Segrave - Monash University
Kate E Hoy - Monash University
Jerome J Maller - Monash University
Paul B Fitzgerald - Monash University
Resource Type: Journal article
Publication Details: Biological psychology, Vol.99(1), pp.115-124
DOI: 10.1016/j.biopsycho.2014.03.008
PMID: 24686072
NLM abbreviation: Biol Psychol
ISSN: 0301-0511
eISSN: 1873-6246
Language: English
Date published: 05/01/2014
Academic Unit: Radiology
Record Identifier: 9984848427902771

Metrics

3 Record Views