Journal article
Impairment of Cingulothalamic Learning-Related Neuronal Coding in Rabbits Exposed to Cocaine In Utero: General and Sex-Specific Effects
Behavioral neuroscience, Vol.113(1), pp.62-77
02/1999
DOI: 10.1037/0735-7044.113.1.62
PMID: 10197907
Abstract
Neuronal activity was recorded in the cingulate cortex and
the limbic thalamus in Dutch-belted rabbits (
Oryctolagus cuniculus
) exposed to cocaine (8
mg/kg/day iv) or saline in utero during acquisition and reversal
learning of a discriminative avoidance response. Anterior cingulate
cortical excitatory training-induced activity (TIA) was attenuated
in cocaine-exposed female rabbits during acquisition and reversal
learning, but only during reversal learning in male rabbits.
Posterior cingulate cortical excitatory TIA was lessened in
cocaine-exposed rabbits during acquisition, whereas discrimination
between the positive and negative cues was enhanced. Neuronal firing
was attenuated in the anterior ventral thalamus in cocaine-exposed
rabbits during acquisition and reversal learning. Behavioral
learning was normal in cocaine-exposed rabbits. Other data suggest
that rabbits exposed to cocaine in utero exhibit a learning deficit
when trained with nonsalient cues.
Details
- Title: Subtitle
- Impairment of Cingulothalamic Learning-Related Neuronal Coding in Rabbits Exposed to Cocaine In Utero: General and Sex-Specific Effects
- Creators
- Carrie L TaylorJohn H FreemanWilliam HoltMichael Gabriel
- Resource Type
- Journal article
- Publication Details
- Behavioral neuroscience, Vol.113(1), pp.62-77
- Publisher
- American Psychological Association
- DOI
- 10.1037/0735-7044.113.1.62
- PMID
- 10197907
- ISSN
- 0735-7044
- eISSN
- 1939-0084
- Language
- English
- Date published
- 02/1999
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984065752102771
Metrics
18 Record Views