Journal article
Impairments of emotion and real-world complex behavior following childhood- or adult-onset damage to ventromedial prefrontal cortex
Journal of the International Neuropsychological Society, Vol.12(2), pp.224-235
03/2006
DOI: 10.1017/S1355617706060346
PMID: 16573856
Abstract
The behavioral syndrome resulting from damage to the ventromedial
prefrontal (VM) region presents major challenges for clinical assessment
and management, stemming from the absence of reliable neurologic or
psychometric markers, coupled with often debilitating impairments of
decision-making and behavior regulation. Damage to this region disrupts
neural circuitry critical for emotion, which in turn may contribute to
impairments in real-world competencies. Here we present findings from
patients with focal lesions in the VM region acquired either in childhood
or adulthood, and show that there is a relationship between emotional
dysfunction and impairments in real-world behavioral competencies. Emotion
was rated by participants' relatives on dimensions including
frustration tolerance, lability, anxiety, and blunted affect. Real-world
competencies were rated by the relatives on dimensions including judgment,
planning, and initiation, and were evaluated by clinician ratings in areas
including social, financial, and occupational function. VM damage resulted
in severe disruption of emotion, and this emotional dysfunction accounted
for a significant portion of impaired real-world competencies. The
long-term impairments associated with childhood-onset lesions were at
least as severe as those resulting from adult-onset damage. Greater focus
on the contribution of emotional dysfunction to the real-world
competencies of patients with damage in the VM region may sharpen their
neuropsychological assessment and facilitate rehabilitation efforts.
(JINS, 2006, 12, 224–235.)
Details
- Title: Subtitle
- Impairments of emotion and real-world complex behavior following childhood- or adult-onset damage to ventromedial prefrontal cortex
- Creators
- STEVEN W ANDERSON - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IowaJOSEPH BARRASH - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IowaANTOINE BECHARA - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, IowaDANIEL TRANEL - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of the International Neuropsychological Society, Vol.12(2), pp.224-235
- DOI
- 10.1017/S1355617706060346
- PMID
- 16573856
- NLM abbreviation
- J Int Neuropsychol Soc
- ISSN
- 1355-6177
- eISSN
- 1469-7661
- Publisher
- Cambridge University Press; New York, USA
- Number of pages
- 12
- Language
- English
- Date published
- 03/2006
- Academic Unit
- Neurology; Psychological and Brain Sciences; Iowa Neuroscience Institute
- Record Identifier
- 9984002592602771
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