Implant surface treatment using biomimetic agents

Gustavo Avila; Kelly Misch; Pablo Galindo-Moreno; Hom-Lay Wang

doi:10.1097/ID.0b013e318192cb7d

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Implant surface treatment using biomimetic agents

Journal article

Peer reviewed

Implant surface treatment using biomimetic agents

Gustavo Avila, Kelly Misch, Pablo Galindo-Moreno and Hom-Lay Wang

Implant dentistry, Vol.18(1), pp.17-26

02/2009

DOI: 10.1097/ID.0b013e318192cb7d

PMID: 19212234

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Abstract

With an attempt at achieving faster osseointegration to hasten the overall treatment process, the use of biomimetic agents represents a growing area of research in implant dentistry. This study outlines 4 categories of bioactive agents that may be applied to coat the titanium implant surface: (1) biocompatible ceramics, (2) bioactive proteins, (3) ions, and (4) polymers, and their respective importance in the early stages of osseointegration. The potential bioactive agents investigated include bone morphogenetic proteins, growth factors, type I collagen, RGD peptide, fluoride, or chitosan, among others. The ideal characteristics that biomimetic agents should uphold and factors that may influence their effectiveness are reviewed. They include implant surface texture, time-oriented delivery vehicle and the ability of the agent to reach a target. Some of these agents, such as bioceramics (calcium phosphate salts) or ions (fluoride) are already commercially available and have shown clinical success. Others such as bone morphogenetic proteins are very promising, with an excellent therapeutic potential. A specific implant surface coating may enhance the percentage of bone-to-implant contact as well as speed of osseointegration that allows clinicians to overcome many challenging clinical scenarios.

Humans

Collagen Type I - chemistry

Osseointegration - physiology

Coated Materials, Biocompatible - chemistry

Intercellular Signaling Peptides and Proteins - chemistry

Fluorides - chemistry

Ceramics - chemistry

Chitosan - chemistry

Dental Materials - chemistry

Surface Properties

Bone Morphogenetic Proteins - chemistry

Dental Implants

Oligopeptides - chemistry

Biomimetic Materials - chemistry

Details

Title: Subtitle: Implant surface treatment using biomimetic agents
Creators: Gustavo Avila - Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078, USA
Kelly Misch
Pablo Galindo-Moreno
Hom-Lay Wang
Resource Type: Journal article
Publication Details: Implant dentistry, Vol.18(1), pp.17-26
Publisher: United States
DOI: 10.1097/ID.0b013e318192cb7d
PMID: 19212234
ISSN: 1056-6163
eISSN: 1538-2982
Language: English
Date published: 02/2009
Academic Unit: Periodontics
Record Identifier: 9984065991802771

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