Journal article
Implementation of an antibiotic prophylaxis protocol in an intensive care unit
AJIC: American Journal of Infection Control, Vol.40(8), pp.721-725
10/2012
DOI: 10.1016/j.ajic.2011.09.018
PMID: 22300894
Abstract
When properly employed, the prophylactic use of antimicrobials is associated with a reduction in surgical site infections (SSIs). We found that the appropriate use of antimicrobial prophylaxis was only 50.5% (53/105) among patients undergoing surgery in the adult intensive care unit of our hospital. In 2001, a protocol was designed to improve compliance with recommended practice. We used a prospective interventional study and a case control study carried out between 2001 and 2007, including follow-up and daily intervention to improve compliance with antimicrobial prophylaxis guidelines and to monitor antimicrobial consumption and SSI rates. Cases of noncompliance to the prophylaxis protocol (group I) were matched to controls (group II) with appropriate prophylaxis and compared with regards to type of surgery, operative duration, intraoperative antimicrobial use, type of antimicrobial used, length of hospital stay, severity of illness, comorbidities, invasive devices, possible adverse reactions, and death. Compliance with antimicrobial prophylaxis metrics reached 85%; however, we were unable to detect a change in SSI rate or consumption and cost of antimicrobials. Inappropriate use was not associated with higher likelihood of death. There were no other significant differences between the 2 groups. Our intervention increased compliance with appropriate antimicrobial surgical prophylaxis with no negative impact on patient safety.
Details
- Title: Subtitle
- Implementation of an antibiotic prophylaxis protocol in an intensive care unit
- Creators
- Silvana Maria de Almeida - Intensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, BrazilAlexandre R Marra - Intensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, BrazilSergio B Wey - Department of Infectious Diseases, Universidade Federal de São Paulo (UNIFESP), São Paulo, BrazilElivane da Silva Victor - Statistics Department, Instituto Israelita de Ensino e Pesquisa (IIEP), São Paulo, BrazilOscar Fernando Pavão dos Santos - Division of Medical Practice, Hospital Israelita Albert Einstein, São Paulo, BrazilMichael B Edmond - Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA
- Resource Type
- Journal article
- Publication Details
- AJIC: American Journal of Infection Control, Vol.40(8), pp.721-725
- Publisher
- Mosby, Inc
- DOI
- 10.1016/j.ajic.2011.09.018
- PMID
- 22300894
- ISSN
- 0196-6553
- eISSN
- 1527-3296
- Language
- English
- Date published
- 10/2012
- Academic Unit
- Infectious Diseases; Internal Medicine
- Record Identifier
- 9983905648702771
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