Implementation of collaborative care for depression in VA HIV clinics: Translating Initiatives for Depression into Effective Solutions (HITIDES): protocol for a cluster-randomized type 3 hybrid effectiveness-implementation trial

Jacob T. Painter; Jeffrey Pyne; Geoffrey Curran; Rebecca A. Raciborski; Shane Russell; John Fortney; Allen L. Gifford; Michael Ohl; Eva N. Woodward

doi:10.1186/s43058-024-00639-z

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Implementation of collaborative care for depression in VA HIV clinics: Translating Initiatives for Depression into Effective Solutions (HITIDES): protocol for a cluster-randomized type 3 hybrid effectiveness-implementation trial

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Implementation of collaborative care for depression in VA HIV clinics: Translating Initiatives for Depression into Effective Solutions (HITIDES): protocol for a cluster-randomized type 3 hybrid effectiveness-implementation trial

Jacob T. Painter, Jeffrey Pyne, Geoffrey Curran, Rebecca A. Raciborski, Shane Russell, John Fortney, Allen L. Gifford, Michael Ohl and Eva N. Woodward

Implementation science communications, Vol.5(1), 99

09/16/2024

DOI: 10.1186/s43058-024-00639-z

PMCID: PMC11404036

PMID: 39285308

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Abstract

Background Depression is the most diagnosed mental health condition among people living with HIV. Collaborative care is an effective intervention for depression, typically delivered in primary care settings. The HIV Translating Initiatives for Depression into Effective Solutions (HITIDES) clinical intervention involves a depression care team housed off-site that supports depression care delivery by HIV care providers. In a randomized controlled trial, HITIDES significantly improved depression symptoms for veterans living with HIV and delivered cost savings. However, no HIV clinics in the Veterans Health Administration (VHA) have implemented HITIDES; as such, it is unclear what implementation strategies are necessary to launch and sustain this intervention. Methods This hybrid type-3 effectiveness-implementation trial examines the implementation and effectiveness of HITIDES in 8 VHA HIV clinics randomly assigned to one of two implementation arms. Each arm uses a different implementation strategy package. Arm 1 includes an intervention operations guide; an on-site clinical champion who, with the help of a peer community of practice, will work with local clinicians and leadership to implement HITIDES at their site; and patient engagement in implementation tools. Arm 2 includes all strategies from Arm 1 with assistance from an external facilitator. The primary implementation outcomes is reach; secondary outcomes include adoption, implementation dose, depressive symptoms, and suicidal ideation. We will conduct a budget impact analysis of the implementation strategy packages. We hypothesize that Arm 2 will be associated with greater reach and adoption and that Arm 1 will be less costly. Discussion Preliminary work identified implementation strategies acceptable to veterans living with HIV and HIV care providers; however, the effectiveness and cost of these strategies are unknown. While the depression care team can deliver services consistently with high quality, the ability of the depression care team to engage with HIV care providers at sites is unknown. Findings from this study will be used to inform selection of implementation strategies for a broad rollout to enhance depression and suicide care for people living with HIV.

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Title: Subtitle: Implementation of collaborative care for depression in VA HIV clinics: Translating Initiatives for Depression into Effective Solutions (HITIDES): protocol for a cluster-randomized type 3 hybrid effectiveness-implementation trial
Creators: Jacob T. Painter - Central Arkansas Veterans Healthcare System
Jeffrey Pyne - University of Arkansas for Medical Sciences
Geoffrey Curran - University of Arkansas for Medical Sciences
Rebecca A. Raciborski - Quality Enhancement Research Initiative
Shane Russell - Health Services Research & Development
John Fortney - University of Washington
Allen L. Gifford - VA Boston Healthcare System
Michael Ohl - Iowa City VA Health Care System
Eva N. Woodward - University of Arkansas for Medical Sciences
Resource Type: Journal article
Publication Details: Implementation science communications, Vol.5(1), 99
Publisher: BioMed Central
DOI: 10.1186/s43058-024-00639-z
PMID: 39285308
PMCID: PMC11404036
ISSN: 2662-2211
eISSN: 2662-2211
Grant note: VA Health Systems Research (HSR) Investigator Initiated ResearchUnited States Department of Veterans Affairs HSR Service: IK2 HX003065 Translational Research Institute (TRI): UL1 TR003107 National Center for Advancing Translational Sciences of the National Institutes of Health (NIH)
This protocol describes work funded by VA Health Systems Research (HSR) Investigator Initiated Research 18-294, awarded to Drs. Painter and Woodward as Multiple Principal Investigators. This work was supported by Career Development Award Number IK2 HX003065 from the United States Department of Veterans Affairs HSR Service (Dr. Woodward). Dr. Curran is supported by the Translational Research Institute (TRI), UL1 TR003107, through the National Center for Advancing Translational Sciences of the National Institutes of Health (NIH).
Language: English
Date published: 09/16/2024
Academic Unit: Psychiatry; Internal Medicine
Record Identifier: 9984708960202771

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