Implementation of discrete element analysis for subject-specific, population-wide investigations of habitual contact stress exposure

Donald D Anderson; Krishna S Iyer; Neil A Segal; John A Lynch; Thomas D Brown

doi:10.1123/jab.26.2.215

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Implementation of discrete element analysis for subject-specific, population-wide investigations of habitual contact stress exposure

Journal article

Peer reviewed

Implementation of discrete element analysis for subject-specific, population-wide investigations of habitual contact stress exposure

Donald D Anderson, Krishna S Iyer, Neil A Segal, John A Lynch and Thomas D Brown

Journal of applied biomechanics, Vol.26(2), pp.215-223

05/2010

DOI: 10.1123/jab.26.2.215

PMCID: PMC2905528

PMID: 20498493

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Abstract

There exist no large-series human data linking contact stress exposure to an articular joint's propensity for developing osteoarthritis because contact stress analysis for large numbers of subjects remains impractical. The speed and simplicity of discrete element analysis (DEA) for estimating contact stresses makes its application to this problem highly attractive, but to date DEA has been used to study only a small numbers of cases. This is because substantial issues regarding its use in population-wide studies have not been addressed. Chief among them are developing fast and robust methods for model derivation and the selection of boundary conditions, establishing accuracy of computed contact stresses, and including capabilities for modeling in-series structural elements (e.g., a meniscus). This article describes an implementation of DEA that makes it feasible to perform subject-specific modeling in articular joints in large population-based studies.

Humans

Stress, Mechanical

Elastic Modulus

Joints - physiopathology

Osteoarthritis - physiopathology

Cartilage, Articular - physiopathology

Cumulative Trauma Disorders - physiopathology

Models, Biological

Computer Simulation

Cumulative Trauma Disorders - complications

Finite Element Analysis

Osteoarthritis - etiology

Population Dynamics

Details

Title: Subtitle: Implementation of discrete element analysis for subject-specific, population-wide investigations of habitual contact stress exposure
Creators: Donald D Anderson - Orthopaedic Biomechanics Laboratory, Department of Orthopaedics & Rehabilitation, as well as the Department of Biomedical Engineering, University of Iowa, Iowa City, IA, USA
Krishna S Iyer
Neil A Segal
John A Lynch
Thomas D Brown
Resource Type: Journal article
Publication Details: Journal of applied biomechanics, Vol.26(2), pp.215-223
Publisher: United States
DOI: 10.1123/jab.26.2.215
PMID: 20498493
PMCID: PMC2905528
ISSN: 1065-8483
eISSN: 1543-2688
Grant note: U01 AG018947 / NIA NIH HHS U01 AG019069-01A1 / NIA NIH HHS U01 AG018832 / NIA NIH HHS K12 HD001097 / NICHD NIH HHS P50 AR055533 / NIAMS NIH HHS U01 AG019069 / NIA NIH HHS K23 AG030945-02 / NIA NIH HHS K23 AG030945 / NIA NIH HHS U01 AG018820-01A1 / NIA NIH HHS AG18820 / NIA NIH HHS 5K12HD001097-08 / NICHD NIH HHS U01 AG018832-01A1 / NIA NIH HHS P50 AR048939 / NIAMS NIH HHS AG19069 / NIA NIH HHS AG18947 / NIA NIH HHS AR48939 / NIAMS NIH HHS AG18832 / NIA NIH HHS U01 AG018947-01A1 / NIA NIH HHS AR55533 / NIAMS NIH HHS P50 AR055533-03 / NIAMS NIH HHS P50 AR048939-03 / NIAMS NIH HHS U01 AG018820 / NIA NIH HHS
Language: English
Date published: 05/2010
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Epidemiology; Orthopedics and Rehabilitation; Industrial and Systems Engineering
Record Identifier: 9984040378602771

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