Implications of Starvation-Induced Change in Right Dorsal Anterior Cingulate Volume in Anorexia Nervosa

Laurie M McCormick; Pamela K Keel; Michael C Brumm; Wayne Bowers; Victor Swayze; Arnold Andersen; Nancy Andreasen

doi:10.1002/eat.20549

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Implications of Starvation-Induced Change in Right Dorsal Anterior Cingulate Volume in Anorexia Nervosa

Journal article

Peer reviewed

Implications of Starvation-Induced Change in Right Dorsal Anterior Cingulate Volume in Anorexia Nervosa

Laurie M McCormick, Pamela K Keel, Michael C Brumm, Wayne Bowers, Victor Swayze, Arnold Andersen and Nancy Andreasen

The International journal of eating disorders, Vol.41(7), pp.602-610

11/2008

DOI: 10.1002/eat.20549

PMCID: PMC3652574

PMID: 18473337

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https://www.ncbi.nlm.nih.gov/pmc/articles/3652574View

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Abstract

Objective: Converging evidence suggests a role for the anterior cingulate cortex (ACC) in the pathophysiology of anorexia nervosa (AN). This study sought to determine whether ACC volume was affected by starvation in active AN and, if so, whether this had any clinical significance. Method: Eighteen patients with active AN and age- and gender-matched normal controls underwent magnetic resonance imaging (MRI). Sixteen patients (89%) with AN had intelligence quotients (IQ) testing at intake, 14 (78%) had repeat MRIs after weight normalization, and 10 (56%) had outcome data at 1-year posthospitalization. Results: Right dorsal ACC volume was significantly reduced in active AN patients versus controls and was correlated with lower performance IQ. While ACC normalization occurred with weight restoration, smaller change in right dorsal ACC volume prospectively predicted relapse after treatment. Conclusion: Reduced right dorsal ACC volume during active AN relates to deficits in perceptual organization and conceptual reasoning. The degree of right dorsal ACC normalization during treatment is related to outcome.

dorsal anterior cingulate

starvation

cognitive function

ACC

performance IQ

MRI

weight restoration

anorexia nervosa

Details

Title: Subtitle: Implications of Starvation-Induced Change in Right Dorsal Anterior Cingulate Volume in Anorexia Nervosa
Creators: Laurie M McCormick - Department of Psychiatry, Veterans Administration, Iowa City, Iowa
Pamela K Keel - Department of Psychiatry, Veterans Administration, Iowa City, Iowa
Michael C Brumm - Department of Psychiatry, Veterans Administration, Iowa City, Iowa
Wayne Bowers - Department of Psychiatry, Veterans Administration, Iowa City, Iowa
Victor Swayze - Department of Psychiatry, Veterans Administration, Iowa City, Iowa
Arnold Andersen - Department of Psychiatry, Veterans Administration, Iowa City, Iowa
Nancy Andreasen - Department of Psychiatry, Veterans Administration, Iowa City, Iowa
Resource Type: Journal article
Publication Details: The International journal of eating disorders, Vol.41(7), pp.602-610
DOI: 10.1002/eat.20549
PMID: 18473337
PMCID: PMC3652574
NLM abbreviation: Int J Eat Disord
ISSN: 0276-3478
eISSN: 1098-108X
Grant note: R01 MH040856 || MH / National Institute of Mental Health : NIMH P50 MH043271 || MH / National Institute of Mental Health : NIMH R37 MH031593 || MH / National Institute of Mental Health : NIMH
Language: English
Date published: 11/2008
Academic Unit: Psychiatry; Iowa Neuroscience Institute
Record Identifier: 9984003932702771

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