Implications of pulse sequence in structural imaging of trabecular bone

Aranee Techawiboonwong; Hee Kwon Song; Jeremy F Magland; Punam K Saha; Felix W Wehrli

doi:10.1002/jmri.20432

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Implications of pulse sequence in structural imaging of trabecular bone

Journal article

Peer reviewed

Implications of pulse sequence in structural imaging of trabecular bone

Aranee Techawiboonwong, Hee Kwon Song, Jeremy F Magland, Punam K Saha and Felix W Wehrli

Journal of magnetic resonance imaging, Vol.22(5), pp.647-655

11/2005

DOI: 10.1002/jmri.20432

PMID: 16215967

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Abstract

To investigate the SNR and image properties of 3D steady-state free precession (SSFP), fast large-angle spin echo (FLASE), gradient-recalled acquisition in steady state (GRASS), and spoiled GRASS (SPGR) for structural imaging of trabecular bone (TB). SNR was examined theoretically and experimentally on phantoms, bone specimens, and in vivo. The bone volume fraction, TB thickness, and echo time (TE) dependence of the thickness were compared. The trabecula was modeled as a cylinder in simulations to examine the intra-voxel spin-dephasing in SSFP and GRASS. Images were acquired on a 1.5 T Siemens Sonata system (40 mT/m maximum gradient, 200 T/m/s peak slew rate). Within the hardware and safety limit constraints, SNR of FLASE was superior, followed by SSFP, GRASS, and SPGR. The trabecular thickness derived from gradient-echo images was 10-45% greater than that obtained with FLASE. Conversely, SSFP images delineated partial volume trabeculae better than FLASE. Simulations indicated that the artifactual thickening was more severe in SSFP than in GRASS, which was attributed to off-resonance effects from the induced gradients at the bone/marrow interface. FLASE had the highest SNR and was insensitive to susceptibility dephasing. Although SSFP has superior SNR compared to GRASS, off-resonance effects and duty cycle limitations may compromise its practicality in this application. Inc.

Algorithms

Magnetic Resonance Imaging - instrumentation

Humans

Image Interpretation, Computer-Assisted - methods

Sensitivity and Specificity

Imaging, Three-Dimensional - methods

Magnetic Resonance Imaging - methods

Signal Processing, Computer-Assisted

Image Enhancement - methods

Phantoms, Imaging

Bone and Bones - cytology

Details

Title: Subtitle: Implications of pulse sequence in structural imaging of trabecular bone
Creators: Aranee Techawiboonwong - Laboratory for Structural NMR Imaging, Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
Hee Kwon Song
Jeremy F Magland
Punam K Saha
Felix W Wehrli
Resource Type: Journal article
Publication Details: Journal of magnetic resonance imaging, Vol.22(5), pp.647-655
Publisher: United States
DOI: 10.1002/jmri.20432
PMID: 16215967
ISSN: 1053-1807
eISSN: 1522-2586
Grant note: R01 AR49553 / NIAMS NIH HHS R01 AR41443 / NIAMS NIH HHS
Language: English
Date published: 11/2005
Academic Unit: Radiology; Electrical and Computer Engineering
Record Identifier: 9984051549702771

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