Journal article
Imprinting of Stöber particles for chirally-resolved adsorption of target monosaccharides and disaccharides
New journal of chemistry, Vol.41(20), pp.11525-11532
2017
DOI: 10.1039/C7NJ01938F
Abstract
A simple, inexpensive, and tunable imprinting technique to produce nonporous particles for selective chirally-resolved adsorption of saccharides has been developed. A sugar-based surfactant is added early in the Stöber particle synthesis process (60 seconds after the silica precursor addition) to create molecularly imprinted sites on the surface of the silica particles which are sensitive to the chirality of carbohydrate adsorbates. Mixtures of hexadecyltrimethylammonium bromide (CTAB), and n-octyl-β-d-glucopyranoside (C8G1) or n-dodecyl-β-d-maltopyranoside (C12G2) are employed to target adsorption of d-glucose or d-maltose, respectively. The adsorption of d-glucose on these imprinted materials is enhanced by almost 1.5 times over adsorption of other hexoses like d-mannose and d-galactose which differ by a change at only one chiral center. d-Glucose showed a difference in adsorption of greater than 3 times over the enantiomer l-glucose. Materials imprinted to target d-maltose showed nearly 5 times enhancement in adsorption of d-maltose over cellobiose at the lowest tested concentration. This study shows that a direct molecular imprinting approach of the surface of freshly prepared, soft silica particles can yield particles that exhibit preferential adsorption for a chiral target over similar molecules differing by one or more chiral centers, or by the anomeric attachment within polysaccharides.
Details
- Title: Subtitle
- Imprinting of Stöber particles for chirally-resolved adsorption of target monosaccharides and disaccharides
- Creators
- Suvid Joshi - Ingevity Corporation, North Charleston, USAHans-Joachim Lehmler - Department of Occupational and Environmental Health, University of Iowa, Iowa City, USABarbara L Knutson - Department of Chemical and Materials Engineering, University of Kentucky, Lexington, USAStephen E Rankin - Department of Chemical and Materials Engineering, University of Kentucky, Lexington, USA
- Resource Type
- Journal article
- Publication Details
- New journal of chemistry, Vol.41(20), pp.11525-11532
- DOI
- 10.1039/C7NJ01938F
- ISSN
- 1144-0546
- eISSN
- 1369-9261
- Grant note
- DOI: 10.13039/100005825, name: National Institute of Food and Agriculture, award: 2011-10006-30363, 68-3A75-7-608; DOI: 10.13039/100000146, name: Division of Chemical, Bioengineering, Environmental, and Transport Systems, award: CBET-0967381, CBET-0967390
- Language
- English
- Date published
- 2017
- Academic Unit
- Occupational and Environmental Health; Iowa Neuroscience Institute
- Record Identifier
- 9984001087202771
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