Journal article
Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma
The New England journal of medicine, Vol.367(2), pp.107-114
07/12/2012
DOI: 10.1056/NEJMoa1203421
PMID: 22663011
Abstract
BACKGROUND
Activating mutations in serine-threonine protein kinase B-RAF (BRAF) are found in 50% of patients with advanced melanoma. Selective BRAF-inhibitor therapy improves survival, as compared with chemotherapy, but responses are often short-lived. In previous trials, MEK inhibition appeared to be promising in this population.
METHODS
In this phase 3 open-label trial, we randomly assigned 322 patients who had metastatic melanoma with a V600E or V600K BRAF mutation to receive either trametinib, an oral selective MEK inhibitor, or chemotherapy in a 2: 1 ratio. Patients received trametinib (2 mg orally) once daily or intravenous dacarbazine (1000 mg per square meter of body-surface area) or paclitaxel (175 mg per square meter) every 3 weeks. Patients in the chemotherapy group who had disease progression were permitted to cross over to receive trametinib. Progression-free survival was the primary end point, and overall survival was a secondary end point.
RESULTS
Median progression-free survival was 4.8 months in the trametinib group and 1.5 months in the chemotherapy group (hazard ratio for disease progression or death in the trametinib group, 0.45; 95% confidence interval [CI], 0.33 to 0.63; P<0.001). At 6 months, the rate of overall survival was 81% in the trametinib group and 67% in the chemotherapy group despite crossover (hazard ratio for death, 0.54; 95% CI, 0.32 to 0.92; P=0.01). Rash, diarrhea, and peripheral edema were the most common toxic effects in the trametinib group and were managed with dose interruption and dose reduction; asymptomatic and reversible reduction in the cardiac ejection fraction and ocular toxic effects occurred infrequently. Secondary skin neoplasms were not observed.
CONCLUSIONS
Trametinib, as compared with chemotherapy, improved rates of progression-free and overall survival among patients who had metastatic melanoma with a BRAF V600E or V600K mutation. (Funded by GlaxoSmithKline; METRIC ClinicalTrials.gov number, NCT01245062.)
Details
- Title: Subtitle
- Improved Survival with MEK Inhibition in BRAF-Mutated Melanoma
- Creators
- Keith T. Flaherty - Massachusetts General HospitalCaroline Robert - InsermPeter Hersey - The University of SydneyPaul Nathan - NorthwoodClaus Garbe - University of TübingenMohammed Milhem - Univ Iowa Hosp & Clin, Dept Internal Med, Iowa City, IA 52242 USALev V. Demidov - NN Blokhin Russian Canc Res Ctr, Moscow, RussiaJessica C. HasselPiotr Rutkowski - The Maria Sklodowska-Curie National Research Institute of OncologyPeter Mohr - Elbekliniken Buxtehude, Buxtehude, GermanyReinhard Dummer - University of ZurichUwe Trefzer - Charite, D-13353 Berlin, GermanyJames M. G. Larkin - Royal Marsden Hosp, London SW3 6JJ, EnglandJochen Utikal - Heidelberg UniversityBrigitte Dreno - Hop Hotel Dieu, Dept Dermatooncol, CHU Nantes, Nantes, FranceMarta Nyakas - Oslo Univ Hosp, Dept Clin Canc Res, Oslo, NorwayMark R. Middleton - Churchill Hosp, Oxford Natl Inst Hlth Res, Biomed Res Ctr, Dept Oncol, Oxford OX3 7LJ, EnglandJuergen C. Becker - Austrian Society of Dermatology and VenereologyMichelle Casey - GlaxoSmithKline, Collegeville, PA USALaurie J. Sherman - GlaxoSmithKline, Collegeville, PA USAFrank S. Wu - GlaxoSmithKline, Collegeville, PA USADaniele Ouellet - GlaxoSmithKline, Collegeville, PA USAAnne-Marie Martin - GlaxoSmithKline, Collegeville, PA USAKiran Patel - GlaxoSmithKline, Collegeville, PA USADirk Schadendorf - Univ Hosp Essen, Dept Dermatol, Essen, GermanyMETRIC Study Group
- Resource Type
- Journal article
- Publication Details
- The New England journal of medicine, Vol.367(2), pp.107-114
- DOI
- 10.1056/NEJMoa1203421
- PMID
- 22663011
- NLM abbreviation
- N Engl J Med
- ISSN
- 0028-4793
- eISSN
- 1533-4406
- Publisher
- Massachusetts Medical Soc
- Number of pages
- 8
- Grant note
- GlaxoSmithKline
- Language
- English
- Date published
- 07/12/2012
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
- Record Identifier
- 9984359818202771
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