Improved overall survival in acute myeloid leukemia over the last 15 years

Shailesh Simkhada; Luna Acharya; Bradley Loeffler; Aditya Ravindra; Abhishree Pyakuryal; Spriha Parajuli; Vijaya Raj Bhatt; Prajwal Dhakal

doi:10.1080/10428194.2026.2635662

Back

Improved overall survival in acute myeloid leukemia over the last 15 years

Journal article

Peer reviewed

Improved overall survival in acute myeloid leukemia over the last 15 years

Shailesh Simkhada, Luna Acharya, Bradley Loeffler, Aditya Ravindra, Abhishree Pyakuryal, Spriha Parajuli, Vijaya Raj Bhatt and Prajwal Dhakal

Leukemia & lymphoma

03/07/2026

DOI: 10.1080/10428194.2026.2635662

PMID: 41793418

View Online

Abstract

This study evaluated changes in overall survival (OS) among patients diagnosed with AML from 2004 to 2019 using the National Cancer Database. The analysis included 67,895 patients aged ≥ 18 years, divided into three diagnosis eras: 2004-2010, 2011-2016, and 2017-2019. Median OS steadily improved over time: 7.6 months in 2004-2010, 8.6 months in 2011-2016, and 10.4 months in 2017-2019. The impact of age, AML subtype, chemotherapy, and HCT on OS changed over time, especially showing a stronger positive association with chemotherapy and HCT after 2017. OS remained lower in males, non-Hispanics, racial groups other than Black or White, individuals with a CCI> 0, those with public or no insurance, and those with an annual income <$35000. Our findings demonstrate that survival has improved significantly, coinciding with the introduction of venetoclax-based regimens and targeted therapies for FLT3 and IDH1/2 mutations, although disparities by socioeconomic factors persist.

Chemotherapy

overall survival

hematopoeitic cell transplantation

Acute myeloid leukemia

survival disparities

Details

Title: Subtitle: Improved overall survival in acute myeloid leukemia over the last 15 years
Creators: Shailesh Simkhada - Trinity Health
Luna Acharya - University of Iowa
Bradley Loeffler - University of Iowa
Aditya Ravindra - University of Iowa
Abhishree Pyakuryal - Tribhuvan University
Spriha Parajuli - Kathmandu University
Vijaya Raj Bhatt - University of Nebraska Medical Center
Prajwal Dhakal - University of Iowa
Resource Type: Journal article
Publication Details: Leukemia & lymphoma
DOI: 10.1080/10428194.2026.2635662
PMID: 41793418
NLM abbreviation: Leuk Lymphoma
ISSN: 1029-2403
eISSN: 1029-2403
Publisher: Taylor & Francis
Grant note: Holden Comprehensive Cancer Center and the Department of Internal Medicine
This study was supported by an institutional grant from the Holden Comprehensive Cancer Center and the Department of Internal Medicine.
Language: English
Electronic publication date: 03/07/2026
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9985141896802771

Metrics

1 Record Views