Journal article
Improved reconstruction stability for chemical shift encoded hyperpolarized C-13 magnetic resonance spectroscopic imaging using k-t spiral acquisitions
Magnetic resonance in medicine, Vol.84(1), pp.25-38
07/01/2020
DOI: 10.1002/mrm.28122
PMCID: PMC7083691
PMID: 31814173
Abstract
Purpose: A multiecho, field of view (FOV)-oversampled k-t spiral acquisition and direct iterative decomposition of water and fat with echo asymmetry and least-squares estimation reconstruction is demonstrated to improve the stability of hyperpolarized C-13 magnetic resonance spectroscopic imaging (MRSI) in the presence of signal ambiguities attributed to low-SNR (signal-to-noise-ratio) species, local uncertainties in metabolite peaks, and echo-to-echo signal inconsistencies.
Theory: k-t spiral acquisitions redistribute readout points to be more densely spaced radially in k-space by acquiring an FOV and matrix that are oversampled by eta. These more densely spaced spiral turns constitute effective intraspiral echoes and can supplement conventional interspiral echoes to improve spectral separation and reduce spectral cross-talk to better resolve C-13-labeled species for spectroscopic imaging.
Methods: Digital simulations and imaging phantom experiments were performed for a range of interspiral echo spacings and eta using multiecho, k-t spiral acquisitions. Image spectral cross-talk artifacts were evaluated both qualitatively and quantitatively as the percent error in measured metabolite ratios. In vivo murine experiments evaluated the feasibility of multiecho, k-t spiral [1-C-13]pyruvate MRSI to reduce spectral cross-talk for 3 scenarios of different expected reconstruction stability.
Results: Digital simulations and imaging phantom experiments both demonstrated reduced or comparable image spectral cross-talk and percent errors in measured metabolite ratios with increasing eta and better choices of echo spacings. In vivo images displayed markedly reduced spectral cross-talk in lactate images acquired with eta = 7 versus eta = 1.
Conclusion: The precision of hyperpolarized C-13 metabolic imaging and quantification in the presence of low-SNR species, local uncertainties in metabolite resonances, and echo-to-echo signal inconsistencies can be improved with the use of FOV-oversampled k-t spiral acquisitions.
Details
- Title: Subtitle
- Improved reconstruction stability for chemical shift encoded hyperpolarized C-13 magnetic resonance spectroscopic imaging using k-t spiral acquisitions
- Creators
- Erin B. Macdonald - University of Wisconsin–MadisonGregory P. Barton - University of Wisconsin–MadisonBenjamin L. Cox - Morgridge Institute for ResearchKevin M. Johnson - University of Wisconsin–MadisonRoberta M. Strigel - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Magnetic resonance in medicine, Vol.84(1), pp.25-38
- DOI
- 10.1002/mrm.28122
- PMID
- 31814173
- PMCID
- PMC7083691
- NLM abbreviation
- Magn Reson Med
- ISSN
- 0740-3194
- eISSN
- 1522-2594
- Publisher
- Wiley
- Number of pages
- 14
- Grant note
- R01 DK092454 / National Institute of Diabetes and Digestive and Kidney Diseases; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) Department of Radiology, University of Wisconsin-Madison UL1TR000427 / National Center for Advancing Translational Sciences; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS) American Association of Physicists in Medicine Department of Medical Physics, University of Wisconsin-Madison GE Healthcare; General Electric UL1TR000427 / Radiological Society of North America
- Language
- English
- Date published
- 07/01/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984275058602771
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