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Improvements in Efficiency and Selectivity for C–F Bond Halogen-Exchange Reactions using Boron Reagents
Journal article   Peer reviewed

Improvements in Efficiency and Selectivity for C–F Bond Halogen-Exchange Reactions using Boron Reagents

Andrej Corkovic, Andreas Dorian and Florence Williams
Synlett, Vol.34(3), pp.193-202
2023
DOI: 10.1055/a-1941-2205

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Abstract

The use of boron Lewis acids as instigators of bond cleavage offers a number of synthetic possibilities. A unique feature of this class of reagents is the capability to functionalize traditionally inert C–F bonds. We summarize notable developments of C–F bond halogen exchange using Lewis acidic boron reagents and conclude by featuring our group’s advances in activating CF3 groups using boron trihalides.
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