Journal article
Improvements in strength and agility measures of functional fitness following a telehealth-delivered home-based exercise intervention in endometrial cancer survivors
Supportive care in cancer, Vol.30(1), pp.447-455
01/2022
DOI: 10.1007/s00520-021-06415-2
PMCID: PMC9362897
PMID: 34304292
Abstract
Endometrial cancer is strongly linked to obesity and inactivity; however, increased physical activity has important benefits even in the absence of weight loss. Resistance (strength) training can deliver these benefits; yet few women participate in resistance exercise. The purpose of this study was to describe both physiological and functional changes following a home-based strength training intervention.
Forty post-treatment endometrial cancer survivors within 5 years of diagnosis were enrolled in a pilot randomized trial, comparing twice-weekly home-based strength exercise to wait list control. Participants conducted the exercises twice per week for 10 supervised weeks with 5 weeks of follow-up. Measures included DXA-measured lean mass, functional fitness assessments, blood biomarkers, and quality of life outcomes.
On average, participants were 60.9 years old (SD = 8.7) with BMI of 39.9 kg/m
(SD = 15.2). At baseline, participants had 51.2% (SD = 6.0) body fat, which was not different between groups. Improvements were seen in the 30-s chair sit to stand (d = .99), the 30-s arm curl (d = .91), and the 8-ft up-and-go test (d = .63). No changes were measured for HbA1c or C-reactive protein. No changes were observed for flexibility (chair sit and reach, back scratch tests), 6-min walk test, maximum handgrip test, anxiety, depression, fatigue, or self-efficacy for exercise.
Home-based muscle-strengthening exercise led to favorable and clinically relevant improvements in 3 of 7 physical function assessments. Physical function, body composition, blood biomarkers, and patient-reported outcomes were feasible to measure. These fitness improvements were observed over a relatively short time frame of 10 weeks.
Details
- Title: Subtitle
- Improvements in strength and agility measures of functional fitness following a telehealth-delivered home-based exercise intervention in endometrial cancer survivors
- Creators
- Jessica S Gorzelitz - University of Wisconsin–MadisonStefanie Stoller - Duke UniversityErin Costanzo - University of Wisconsin–MadisonRonald Gangnon - University of Wisconsin–MadisonKelli Koltyn - University of Wisconsin–MadisonAmy Trentham Dietz - University of Wisconsin–MadisonRyan J Spencer - University of Wisconsin–MadisonJoanne Rash - University of Wisconsin–MadisonLisa Cadmus-Bertram - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Supportive care in cancer, Vol.30(1), pp.447-455
- DOI
- 10.1007/s00520-021-06415-2
- PMID
- 34304292
- PMCID
- PMC9362897
- NLM abbreviation
- Support Care Cancer
- ISSN
- 0941-4355
- eISSN
- 1433-7339
- Grant note
- 2P30CA014520-44 / University of Wisconsin Carbone Cancer Center 1R03CA230965-01A1 / Division of Cancer Epidemiology and Genetics, National Cancer Institute IRG-15-213-51 / American Cancer Society
- Language
- English
- Date published
- 01/2022
- Academic Unit
- Health, Sport, and Human Physiology
- Record Identifier
- 9984295023802771
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