Improving Pain Management and Long-Term Outcomes Following High-Energy Orthopaedic Trauma (Pain Study)

Renan C Castillo; Srinivasa N Raja; Katherine P Frey; Heather A Vallier; Paul Tornetta III; Todd Jaeblon; Brandon J Goff; Allan Gottschalk; Daniel O Scharfstein; Robert V OʼToole; Major Extremity Trauma Research Consortium (METRC)

doi:10.1097/BOT.0000000000000793

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Improving Pain Management and Long-Term Outcomes Following High-Energy Orthopaedic Trauma (Pain Study)

Journal article

Peer reviewed

Improving Pain Management and Long-Term Outcomes Following High-Energy Orthopaedic Trauma (Pain Study)

Renan C Castillo, Srinivasa N Raja, Katherine P Frey, Heather A Vallier, Paul Tornetta III, Todd Jaeblon, Brandon J Goff, Allan Gottschalk, Daniel O Scharfstein, Robert V OʼToole, …

Journal of orthopaedic trauma, Vol.31 Suppl 1(1), pp.S71-S77

04/2017

DOI: 10.1097/BOT.0000000000000793

PMID: 28323806

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Abstract

Poor pain control after orthopaedic trauma is a predictor of physical disability and numerous negative long-term outcomes. Despite increased awareness of the negative consequences of poorly controlled pain, analgesic therapy among hospitalized patients after orthopaedic trauma remains inconsistent and often inadequate. The Pain study is a 3 armed, prospective, double-blind, multicenter randomized trial designed to evaluate the effect of standard pain management versus standard pain management plus perioperative nonsteroidal anti-inflammatory drugs or pregabalin in patients of ages 18-85 with extremity fractures. The primary outcomes are chronic pain, opioid utilization during the 48 hours after definitive fixation and surgery for nonunion in the year after fixation. Secondary outcomes include preoperative and postoperative pain intensity, adverse events and complications, physical function, depression, and post-traumatic stress disorder. One year treatment costs are also compared between the groups.

United States

Pain, Postoperative - etiology

Chronic Pain - diagnosis

Prospective Studies

Chronic Pain - prevention & control

Humans

Middle Aged

Male

Young Adult

Aged, 80 and over

Adult

Female

Chronic Pain - etiology

Fracture Fixation - adverse effects

Double-Blind Method

Pain Management - methods

Pain Measurement - drug effects

Treatment Outcome

Pain, Postoperative - prevention & control

Drug Therapy, Combination - methods

Pain, Postoperative - diagnosis

Quality Improvement

Analgesics, Opioid - administration & dosage

Adolescent

Anti-Inflammatory Agents, Non-Steroidal - administration & dosage

Aged

Longitudinal Studies

Details

Title: Subtitle: Improving Pain Management and Long-Term Outcomes Following High-Energy Orthopaedic Trauma (Pain Study)
Creators: Renan C Castillo - Johns Hopkins University
Srinivasa N Raja
Katherine P Frey
Heather A Vallier
Paul Tornetta III
Todd Jaeblon
Brandon J Goff
Allan Gottschalk
Daniel O Scharfstein
Robert V OʼToole
Major Extremity Trauma Research Consortium (METRC)
Contributors: Michael C Willey (Contributor) - University of Iowa, Orthopedics and Rehabilitation
Resource Type: Journal article
Publication Details: Journal of orthopaedic trauma, Vol.31 Suppl 1(1), pp.S71-S77
DOI: 10.1097/BOT.0000000000000793
PMID: 28323806
NLM abbreviation: J Orthop Trauma
ISSN: 0890-5339
eISSN: 1531-2291
Language: English
Date published: 04/2017
Academic Unit: Orthopedics and Rehabilitation; Injury Prevention Research Center
Record Identifier: 9984083877102771

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35 Times Cited - Web of Science

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