Impulsivity across the course of bipolar disorder

Stephen M Strakowski; David E Fleck; Melissa P DelBello; Caleb M Adler; Paula K Shear; Renu Kotwal; Stephan Arndt

doi:10.1111/j.1399-5618.2010.00806.x

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Impulsivity across the course of bipolar disorder

Journal article

Peer reviewed

Impulsivity across the course of bipolar disorder

Stephen M Strakowski, David E Fleck, Melissa P DelBello, Caleb M Adler, Paula K Shear, Renu Kotwal and Stephan Arndt

Bipolar disorders, Vol.12(3), pp.285-297

05/2010

DOI: 10.1111/j.1399-5618.2010.00806.x

PMID: 20565435

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Abstract

To determine whether abnormalities of impulse control persist across the course of bipolar disorder, thereby representing potential state markers and endophenotypes. Impulse control of 108 bipolar I manic or mixed patients was measured on three tasks designed to study response inhibition, ability to delay gratification, and attention; namely, a stop signal task, a delayed reward task, and a continuous performance task, respectively. Barrett Impulsivity Scale (BIS-11) scores were also obtained. Patients were then followed for up to one year and reassessed with the same measures if they developed depression or euthymia. Healthy comparison subjects were also assessed with the same instruments on two occasions to assess measurement stability. At baseline, bipolar subjects demonstrated significant deficits on all three tasks as compared to healthy subjects, consistent with more impulsive responding in the bipolar manic/mixed group. In general, performance on the three behavioral tasks normalized upon switching to depression or developing euthymia. In contrast, BIS-11 scores were elevated during mania and remained elevated as bipolar subjects developed depression or achieved euthymia. Bipolar I disorder patients demonstrate deficits on laboratory tests of various aspects of impulsivity when manic, as compared to healthy subjects, that largely normalize with recovery and switching into depression. However, elevated BIS-11 scores persist across phases of illness. These findings suggest that impulsivity has both affective-state dependent and trait components in bipolar disorder.

Adult

Attention Deficit Disorder with Hyperactivity - etiology

Bipolar Disorder - classification

Bipolar Disorder - complications

Female

Follow-Up Studies

Humans

Impulsive Behavior - diagnosis

Impulsive Behavior - etiology

Male

Neuropsychological Tests

Psychiatric Status Rating Scales

Young Adult

Details

Title: Subtitle: Impulsivity across the course of bipolar disorder
Creators: Stephen M Strakowski - University of Cincinnati Medical Center
David E Fleck - University of Cincinnati Medical Center
Melissa P DelBello
Caleb M Adler - University of Cincinnati Medical Center
Paula K Shear - University of Cincinnati Medical Center
Renu Kotwal
Stephan Arndt - University of Iowa
Resource Type: Journal article
Publication Details: Bipolar disorders, Vol.12(3), pp.285-297
DOI: 10.1111/j.1399-5618.2010.00806.x
PMID: 20565435
ISSN: 1398-5647
eISSN: 1399-5618
Grant note: K23 MH064086 / NIMH NIH HHS K23 MH063373 / NIMH NIH HHS MH066626 / NIMH NIH HHS MH064086 / NIMH NIH HHS MH070849 / NIMH NIH HHS K23 MH070849 / NIMH NIH HHS MH063373 / NIMH NIH HHS R01 MH066626 / NIMH NIH HHS
Language: English
Date published: 05/2010
Academic Unit: Psychiatry; Biostatistics; Nursing; Injury Prevention Research Center
Record Identifier: 9985132069002771

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