In-Hospital Adverse Events of Pheochromocytoma-Induced Takotsubo Syndrome: A Literature Review and Cluster Analysis of 172 Cases

Mei Xu; Qianglin Guan; Tianmin Liu; Yuxi Huang; Cunxue Pan; Liyun Luo; Wenyi Tang; Junwei Xu; Hsi Huang; Li Xiao; Kan Liu; Jian Chen

doi:10.31083/j.rcm2506216

Back

In-Hospital Adverse Events of Pheochromocytoma-Induced Takotsubo Syndrome: A Literature Review and Cluster Analysis of 172 Cases

Journal article

Open access

Peer reviewed

In-Hospital Adverse Events of Pheochromocytoma-Induced Takotsubo Syndrome: A Literature Review and Cluster Analysis of 172 Cases

Mei Xu, Qianglin Guan, Tianmin Liu, Yuxi Huang, Cunxue Pan, Liyun Luo, Wenyi Tang, Junwei Xu, Hsi Huang, Li Xiao, …

Reviews in cardiovascular medicine, Vol.25(6), 216

06/14/2024

DOI: 10.31083/j.rcm2506216

PMCID: PMC11270063

PMID: 39076320

Files and links (1)

url

https://doi.org/10.31083/j.rcm2506216View

Published (Version of record) Open Access

Abstract

Background: Pheochromocytoma-induced takotsubo syndrome (Pheo-TTS) significantly increases the risk of adverse events for inpatient. The early identification of risk factors at admission is crucial for effective risk stratification and minimizing complications in Pheo-TTS patients. Methods: We conducted a systematic review combined with hierarchical cluster and feature importance analysis of demographic, clinical and laboratory data upon admission, alongside in-hospital complication data for Pheo-TTS patients. We analyzed cases published in PubMed and Embase from 2 May 2006 to 27 April 2023. Results: Among 172 Pheo-TTS patients, cluster analysis identified two distinct groups: a chest pain dominant (CPD) group (n = 86) and a non-chest pain dominant (non-CPD) group (n = 86). The non-CPD group was characterized by a younger age (44.0 ± 15.2 vs. 52.4 ± 14.4, p < 0.001), a higher prevalence of neurological/psychiatric disorders (53.5% vs. 32.6%), and increased presentation of dyspnea (87.2% vs. 17.4%), pulmonary rales (59.3% vs. 8.1%), and tachycardia (77.9% vs. 30.2%). Additionally, they exhibited more atypical takotsubo syndrome (TTS) imaging phenotypes (55.8% vs. 36.5%, all p < 0.05). The non-CPD group experienced more than a 2-fold increase for in-hospital adverse events compared to the CPD group (70.9% vs. 30.2%, p < 0.001). After adjusting for confounding factors, the absence of chest pain (odds ratio [OR] = 0.407, 95% confidence interval [CI] 0.169–0.979, p = 0.045), the presence of abdominal symptoms (OR = 3.939, 95% CI 1.770–8.766, p = 0.001), pulmonary rales (OR = 4.348, 95% CI 1.857–10.179, p = 0.001), and atypical TTS imaging phenotype (OR = 3.397, 95% CI 1.534–7.525, p = 0.003) remained as independent predictors of in-hospital complications. Conclusions: Clinical manifestations and imaging features at admission help to predict in-hospital complications for Pheo-TTS patients.

Details

Title: Subtitle: In-Hospital Adverse Events of Pheochromocytoma-Induced Takotsubo Syndrome: A Literature Review and Cluster Analysis of 172 Cases
Creators: Mei Xu
Qianglin Guan - Fifth Affiliated Hospital of Sun Yat-sen University
Tianmin Liu - Fifth Affiliated Hospital of Sun Yat-sen University
Yuxi Huang
Cunxue Pan
Liyun Luo - Fifth Affiliated Hospital of Sun Yat-sen University
Wenyi Tang - Fifth Affiliated Hospital of Sun Yat-sen University
Junwei Xu
Hsi Huang
Li Xiao
Kan Liu - Barnes-Jewish Hospital
Jian Chen - Fifth Affiliated Hospital of Sun Yat-sen University
Resource Type: Journal article
Publication Details: Reviews in cardiovascular medicine, Vol.25(6), 216
DOI: 10.31083/j.rcm2506216
PMID: 39076320
PMCID: PMC11270063
ISSN: 1530-6550
eISSN: 2153-8174
Language: English
Date published: 06/14/2024
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984650259802771

Metrics

3 Record Views