In Situ Fabrication of 3D Ag@ZnO Nanostructures for Microfluidic Surface-Enhanced Raman Scattering Systems

Yuliang Xie; Shikuan Yang; Zhangming Mao; Peng Li; Chenglong Zhao; Zane Cohick; Po-Hsun Huang; Tony Jun Huang

doi:10.1021/nn503826r

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In Situ Fabrication of 3D Ag@ZnO Nanostructures for Microfluidic Surface-Enhanced Raman Scattering Systems

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In Situ Fabrication of 3D Ag@ZnO Nanostructures for Microfluidic Surface-Enhanced Raman Scattering Systems

Yuliang Xie, Shikuan Yang, Zhangming Mao, Peng Li, Chenglong Zhao, Zane Cohick, Po-Hsun Huang and Tony Jun Huang

ACS nano, Vol.8(12), pp.12175-12184

12/23/2014

DOI: 10.1021/nn503826r

PMCID: PMC4278689

PMID: 25402207

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Abstract

In this work, we develop an in situ method to grow highly controllable, sensitive, three-dimensional (3D) surface-enhanced Raman scattering (SERS) substrates via an optothermal effect within microfluidic devices. Implementing this approach, we fabricate SERS substrates composed of Ag@ZnO structures at prescribed locations inside microfluidic channels, sites within which current fabrication of SERS structures has been arduous. Conveniently, properties of the 3D Ag@ZnO nanostructures such as length, packing density, and coverage can also be adjusted by tuning laser irradiation parameters. After exploring the fabrication of the 3D nanostructures, we demonstrate a SERS enhancement factor of up to ∼2 × 10 6 and investigate the optical properties of the 3D Ag@ZnO structures through finite-difference time-domain simulations. To illustrate the potential value of our technique, low concentrations of biomolecules in the liquid state are detected. Moreover, an integrated cell-trapping function of the 3D Ag@ZnO structures records the surface chemical fingerprint of a living cell. Overall, our optothermal-effect-based fabrication technique offers an effective combination of microfluidics with SERS, resolving problems associated with the fabrication of SERS substrates in microfluidic channels. With its advantages in functionality, simplicity, and sensitivity, the microfluidic-SERS platform presented should be valuable in many biological, biochemical, and biomedical applications.

Microfluidics

Ag@ZnO nanostructures

optothermal effect

surface-enhanced Raman scattering (SERS)

Details

Title: Subtitle: In Situ Fabrication of 3D Ag@ZnO Nanostructures for Microfluidic Surface-Enhanced Raman Scattering Systems
Creators: Yuliang Xie - Pennsylvania State University
Shikuan Yang - Pennsylvania State University
Zhangming Mao - Pennsylvania State University
Peng Li - Pennsylvania State University
Chenglong Zhao - Pennsylvania State University
Zane Cohick - Pennsylvania State University
Po-Hsun Huang - Department of Engineering Science and Mechanics and
Tony Jun Huang - Pennsylvania State University
Resource Type: Journal article
Publication Details: ACS nano, Vol.8(12), pp.12175-12184
DOI: 10.1021/nn503826r
PMID: 25402207
PMCID: PMC4278689
NLM abbreviation: ACS Nano
ISSN: 1936-0851
eISSN: 1936-086X
Publisher: American Chemical Society
Grant note: DOI: 10.13039/100000052, name: NIH Office of the Director, award: 1DP2OD007209-01; DOI: 10.13039/100000078, name: Division of Materials Research, award: DMR-0820404
Language: English
Date published: 12/23/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering
Record Identifier: 9984196992602771

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