Journal article
In Vitro Modeling of Human Bocavirus 1 Infection of Polarized Primary Human Airway Epithelia
Journal of virology, Vol.87(7), pp.4097-4102
04/2013
DOI: 10.1128/JVI.03132-12
PMCID: PMC3624236
PMID: 23345515
Abstract
Human bocavirus 1 (HBoV1) is an emerging human-pathogenic respiratory virus. We characterized two important features of HBoV1 infection in polarized primary human airway epithelia (HAE). Apical HBoV1 infection of HAE at a low multiplicity of infection causes disruption of the tight junction barrier, loss of cilia, and epithelial cell hypertrophy, which are hallmarks of the airway epithelial damage caused by HBoV1 infection. HBoV1 also infects HAE from the basolateral surface productively, although less efficiently, and this also leads to the characteristic airway epithelial damage.
Details
- Title: Subtitle
- In Vitro Modeling of Human Bocavirus 1 Infection of Polarized Primary Human Airway Epithelia
- Creators
- Xuefeng Deng - College of Life Sciences, Central China Normal University, Wuhan, ChinaZiying Yan - Department of Anatomy and Cell Biology, College of Medicine, University of Iowa, Iowa City, Iowa, USAYong Luo - Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USAJian Xu - Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USAFang Cheng - Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USAYi Li - College of Life Sciences, Central China Normal University, Wuhan, ChinaJohn F Engelhardt - Department of Anatomy and Cell Biology, College of Medicine, University of Iowa, Iowa City, Iowa, USAJianming Qiu - Department of Microbiology, Molecular Genetics and Immunology, University of Kansas Medical Center, Kansas City, Kansas, USA
- Resource Type
- Journal article
- Publication Details
- Journal of virology, Vol.87(7), pp.4097-4102
- Publisher
- American Society for Microbiology; 1752 N St., N.W., Washington, DC
- DOI
- 10.1128/JVI.03132-12
- PMID
- 23345515
- PMCID
- PMC3624236
- ISSN
- 0022-538X
- eISSN
- 1098-5514
- Language
- English
- Date published
- 04/2013
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Anatomy and Cell Biology; Radiation Oncology; Internal Medicine
- Record Identifier
- 9984025305302771
Metrics
21 Record Views