In Vitro Study of a Medical Device to Enhance Arteriovenous Fistula Eligibility and Maturation

Howard M Loree II; George Agyapong; Elyse G Favreau; Gwendolyn A Ngai; Geoff D Tansley; Bradley S Dixon; F Nicholas Franano

doi:10.1097/MAT.0000000000000240

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In Vitro Study of a Medical Device to Enhance Arteriovenous Fistula Eligibility and Maturation

Journal article

Peer reviewed

In Vitro Study of a Medical Device to Enhance Arteriovenous Fistula Eligibility and Maturation

Howard M Loree II, George Agyapong, Elyse G Favreau, Gwendolyn A Ngai, Geoff D Tansley, Bradley S Dixon and F Nicholas Franano

ASAIO journal (1992), Vol.61(4), pp.480-486

07/2015

DOI: 10.1097/MAT.0000000000000240

PMID: 26120958

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Abstract

The arteriovenous fistula eligibility (AFE) system (Flow Forward Medical, Olathe, KS) is a small, temporary, wearable rotary blood pump system designed to rapidly dilate peripheral veins in hemodialysis patients and improve outcomes after arteriovenous fistula (AVF) creation. A benchtop pulsatile mock circulatory loop was developed to model forearm circulation and to compare the hemodynamics of the AFE system with those of a conventional radiocephalic AVF. The AFE system maintained a mean wall shear stress (mWSS) within the 2.5-7.5 Pa target range for cephalic outflow veins of 2-6 mm diameter, which when applied clinically will provide better control of mWSS during the outflow vein maturation process when compared with a conventional AVF. These results support further study to determine whether or not vein preconditioning with the AFE system under controlled levels of mWSS will promote improved AVF outcomes.

Hemodynamics

Arteriovenous Shunt, Surgical - instrumentation

Infusion Pumps, Implantable

Veins

Models, Biological

Humans

Renal Dialysis - methods

In Vitro Techniques

Details

Title: Subtitle: In Vitro Study of a Medical Device to Enhance Arteriovenous Fistula Eligibility and Maturation
Creators: Howard M Loree II - From the Flow Forward Medical, Inc. (FFM), Lowell, Massachusetts; †School of Engineering, Griffith University, Southport, Queensland, Australia; ‡Department of Internal Medicine, Roy and Lucille Carver College of Medicine, University of Iowa and Veterans Affairs Medical Center, Iowa City, Iowa; and §FFM, Olathe, Kansas
George Agyapong
Elyse G Favreau
Gwendolyn A Ngai
Geoff D Tansley
Bradley S Dixon
F Nicholas Franano
Resource Type: Journal article
Publication Details: ASAIO journal (1992), Vol.61(4), pp.480-486
DOI: 10.1097/MAT.0000000000000240
PMID: 26120958
ISSN: 1058-2916
eISSN: 1538-943X
Language: English
Date published: 07/2015
Academic Unit: Nephrology; Internal Medicine
Record Identifier: 9984094527602771

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