Journal article
In Vivo Evidence for β2 Nicotinic Acetylcholine Receptor Subunit Upregulation in Smokers as Compared With Nonsmokers With Schizophrenia
Biological psychiatry (1969), Vol.76(6), pp.495-502
09/15/2014
DOI: 10.1016/j.biopsych.2013.11.001
PMID: 24360979
Abstract
Schizophrenia is associated with very high rates of tobacco smoking. The latter may be related to an attempt to self-medicate symptoms and/or to alterations in function of high-affinity β2-subunit-containing nicotinic acetylcholine receptors (β2*-nAChRs).
Smoking and nonsmoking subjects with schizophrenia (n = 31) and age-, smoking-, and sex-matched comparison subjects (n = 31) participated in one [123I]5-IA-85380 single photon emission computed tomography scan to quantify β2*-nAChR availability. Psychiatric, cognitive, nicotine craving, and mood assessments were obtained during active smoking, as well as smoking abstinence.
There were no differences in smoking characteristics between smokers with and without schizophrenia. Subjects with schizophrenia had lower β2*-nAChR availability relative to comparison group, and nonsmokers had lower β2*-nAChR availability relative to smokers. However, there was no smoking by diagnosis interaction. Relative to nonsmokers with schizophrenia, smokers with schizophrenia had higher β2*-nAChR availability in limited brain regions. In smokers with schizophrenia, higher β2*-nAChR availability was associated with lower negative symptoms of schizophrenia and better performance on tests of executive control. Chronic exposure to antipsychotic drugs was not associated with changes in β2*-nAChR availability in schizophrenia.
Although subjects with schizophrenia have lower β2*-nAChR availability relative to comparison group, smokers with schizophrenia appear to upregulate in the cortical regions. Lower receptor availability in smokers with schizophrenia in the cortical regions is associated with a greater number of negative symptoms and worse performance on tests of executive function, suggesting smoking subjects with schizophrenia who upregulate to a lesser degree may be at risk for poorer outcomes.
Details
- Title: Subtitle
- In Vivo Evidence for β2 Nicotinic Acetylcholine Receptor Subunit Upregulation in Smokers as Compared With Nonsmokers With Schizophrenia
- Creators
- Irina Esterlis - Department of Psychiatry, School of Medicine, Yale UniversityMohini Ranganathan - Department of Psychiatry, School of Medicine, Yale UniversityFrederic Bois - Department of Psychiatry, School of Medicine, Yale UniversityBrian Pittman - Department of Psychiatry, School of Medicine, Yale UniversityMarina R Picciotto - Department of Psychiatry, School of Medicine, Yale UniversityLara Shearer - Department of Psychiatry, School of Medicine, Yale UniversityAlan Anticevic - Department of Psychiatry, School of Medicine, Yale UniversityJon Carlson - Department of Psychiatry, School of Medicine, Yale UniversityMark J Niciu - Department of Psychiatry, School of Medicine, Yale UniversityKelly P Cosgrove - Department of Psychiatry, School of Medicine, Yale UniversityD. Cyril D’Souza - Department of Psychiatry, School of Medicine, Yale University
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.76(6), pp.495-502
- DOI
- 10.1016/j.biopsych.2013.11.001
- PMID
- 24360979
- NLM abbreviation
- Biol Psychiatry
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Publisher
- Elsevier BV
- Language
- English
- Date published
- 09/15/2014
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984004181102771
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