Journal article
In Vivo Imaging and Spectroscopy of Dynamic Metabolism Using Simultaneous C-13 and H-1 MRI
IEEE transactions on biomedical engineering, Vol.59(1), pp.45-49
01/01/2012
DOI: 10.1109/TBME.2011.2161988
PMCID: PMC3676651
PMID: 21775254
Abstract
Hyperpolarized (HP) C-13-labeled pyruvate studies with magnetic resonance (MR) have been used to observe the kinetics of metabolism in vivo. Kinetic modeling to measure metabolic rates in vivo is currently limited because of nonspecific hyperpolarized signals mixing between vascular, extravascular, and intracellular compartments. In this study, simultaneous acquisition of both H-1 and C-13 signals after contrast agent injection is used to resolve specific compartments to improve the accuracy of the modeling. We demonstrate a novel technique to provide contrast to the intracellular compartments by sequential injection of HP [1-C-13] pyruvate followed by gadolinium-chelate to provide T-1-shortening to extra-cellular compartments. A kinetic model that distinguishes the intracellular space and includes the T-1-shortening effect of the gadolinium chelate can then be used to directly measure the intracellular C-13 kinetics.
Details
- Title: Subtitle
- In Vivo Imaging and Spectroscopy of Dynamic Metabolism Using Simultaneous C-13 and H-1 MRI
- Creators
- Matthew R. Smith - University of Wisconsin–MadisonEric T. Peterson - University of Wisconsin–MadisonJeremy W. Gordon - University of Wisconsin–MadisonDavid J. Niles - University of Wisconsin–MadisonIan J. Rowland - University of Wisconsin–MadisonKrishna N. Kurpad - University of Wisconsin–MadisonSean B. Fain - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- IEEE transactions on biomedical engineering, Vol.59(1), pp.45-49
- DOI
- 10.1109/TBME.2011.2161988
- PMID
- 21775254
- PMCID
- PMC3676651
- NLM abbreviation
- IEEE Trans Biomed Eng
- ISSN
- 0018-9294
- eISSN
- 1558-2531
- Publisher
- IEEE
- Number of pages
- 5
- Grant note
- P50AG033514 / NATIONAL INSTITUTE ON AGING; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA) Wisconsin Alzheimer's Disease Research Center T32CA009206 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) 5 T32 CA009206-28 / NIH/NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) GE Healthcare; General Electric
- Language
- English
- Date published
- 01/01/2012
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984274952102771
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