Journal article
In Vivo Tracking of Cell Therapies for Cardiac Diseases with Nuclear Medicine
Stem cells international, Vol.2016(1), 3140120
01/01/2016
DOI: 10.1155/2016/3140120
PMID: 26880951
Abstract
Even though heart diseases are amongst the main causes of mortality and morbidity in the world, existing treatments are limited in restoring cardiac lesions. Cell transplantations, originally developed for the treatment of hematologic ailments, are presently being explored in preclinical and clinical trials for cardiac diseases. Nonetheless, little is known about the possible efficacy and mechanisms for these therapies and they are the center of continuous investigation. In this scenario, noninvasive imaging techniques lead to greater comprehension of cell therapies. Radiopharmaceutical cell labeling, firstly developed to track leukocytes, has been used successfully to evaluate the migration of cell therapies for myocardial diseases. A substantial rise in the amount of reports employing this methodology has taken place in the previous years. We will review the diverse radiopharmaceuticals, imaging modalities, and results of experimental and clinical studies published until now. Also, we report on current limitations and potential advances of radiopharmaceutical labeling for cell therapies in cardiac diseases.
Details
- Title: Subtitle
- In Vivo Tracking of Cell Therapies for Cardiac Diseases with Nuclear Medicine
- Creators
- Mayra Lorena Moreira - Universidade Federal do Rio de JaneiroPriscylla Da Costa Medeiros - Universidade Federal do Rio de JaneiroSergio Augusto Lopes de Souza - Departamento de Radiologia, Faculdade de Medicina, Universidade Federal Do Rio de Janeiro, Rio de Janeiro, RJ, BrazilBianca Gutfilen - Universidade Federal do Rio de JaneiroPaulo Henrique Rosado-De-Castro - Universidade Federal do Rio de Janeiro
- Resource Type
- Journal article
- Publication Details
- Stem cells international, Vol.2016(1), 3140120
- DOI
- 10.1155/2016/3140120
- PMID
- 26880951
- NLM abbreviation
- Stem Cells Int
- ISSN
- 1687-9678
- eISSN
- 1687-9678
- Grant note
- Conselho Nacional de Desenvolvimento Científico e Tecnológico Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (http://data.elsevier.com/vocabulary/SciValFunders/501100004586) Conselho Nacional de Desenvolvimento Científico e Tecnológico (http://data.elsevier.com/vocabulary/SciValFunders/501100003593) Conselho Nacional de Desenvolvimento Cientifico e Tecnologico
- Language
- English
- Date published
- 01/01/2016
- Academic Unit
- Radiology
- Record Identifier
- 9985143124402771
Metrics
1 Record Views