In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem

Sixiang Shi; Feng Chen; Shreya Goel; Stephen A. Graves; Haiming Luo; Charles P. Theuer; Jonathan W. Engle; Weibo Cai

doi:10.1007/s40820-018-0216-2

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In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem

Journal article

Open access

Peer reviewed

In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem

Sixiang Shi, Feng Chen, Shreya Goel, Stephen A. Graves, Haiming Luo, Charles P. Theuer, Jonathan W. Engle and Weibo Cai

Nano-micro letters, Vol.10(4), pp.65-11

10/01/2018

DOI: 10.1007/s40820-018-0216-2

PMCID: PMC6199109

PMID: 30393713

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Abstract

Silica nanoparticles have been one of the most promising nanosystems for biomedical applications due to their facile surface chemistry and non-toxic nature. However, it is still challenging to effectively deliver them into tumor sites and noninvasively visualize their in vivo biodistribution with excellent sensitivity and accuracy for effective cancer diagnosis. In this study, we design a yolk/shell-structured silica nanosystem Cu-64-NOTA-QD@HMSN-PEG-TRC105, which can be employed for tumor vasculature targeting and dual-modality PET/optical imaging, leading to superior targeting specificity, excellent imaging capability and more reliable diagnostic outcomes. By combining vasculature targeting, pH-sensitive drug delivery, and dual-modality imaging into a single platform, as-designed yolk/shell-structured silica nanosystems may be employed for the future image-guided tumor-targeted drug delivery, to further enable cancer theranostics.

Materials Science

Materials Science, Multidisciplinary

Nanoscience & Nanotechnology

Physical Sciences

Physics

Physics, Applied

Science & Technology

Science & Technology - Other Topics

Technology

Details

Title: Subtitle: In Vivo Tumor-Targeted Dual-Modality PET/Optical Imaging with a Yolk/Shell-Structured Silica Nanosystem
Creators: Sixiang Shi - University of Wisconsin–Madison
Feng Chen - University of Wisconsin–Madison
Shreya Goel - University of Wisconsin–Madison
Stephen A. Graves - University of Wisconsin–Madison
Haiming Luo - University of Wisconsin–Madison
Charles P. Theuer - Tracon Pharmaceuticals (United States)
Jonathan W. Engle - University of Wisconsin–Madison
Weibo Cai - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: Nano-micro letters, Vol.10(4), pp.65-11
DOI: 10.1007/s40820-018-0216-2
PMID: 30393713
PMCID: PMC6199109
NLM abbreviation: Nanomicro Lett
ISSN: 2311-6706
eISSN: 2150-5551
Publisher: Springer Nature
Number of pages: 11
Grant note: P30CA014520 / NATIONAL CANCER INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) 125246-RSG-13-099-01-CCE / American Cancer Society P30CA014520; T32CA009206 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA University of Wisconsin-Madison
Language: English
Date published: 10/01/2018
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology
Record Identifier: 9984383883902771

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