In Vivo Tumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine

Feng Chen; Hao Hong; Shreya Goel; Stephen A Graves; Hakan Orbay; Emily B Ehlerding; Sixiang Shi; Charles P Theuer; Robert J Nickles; Weibo Cai

doi:10.1021/nn507241v

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In Vivo Tumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine

Journal article

Open access

Peer reviewed

In Vivo Tumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine

Feng Chen, Hao Hong, Shreya Goel, Stephen A Graves, Hakan Orbay, Emily B Ehlerding, Sixiang Shi, Charles P Theuer, Robert J Nickles and Weibo Cai

ACS nano, Vol.9(4), pp.3926-3934

04/28/2015

DOI: 10.1021/nn507241v

PMCID: PMC4414921

PMID: 25843647

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https://doi.org/10.1021/nn507241vView

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Abstract

Actively targeted theranostic nanomedicine may be the key for future personalized cancer management. Although numerous types of theranostic nanoparticles have been developed in the past decade for cancer treatment, challenges still exist in the engineering of biocompatible theranostic nanoparticles with highly specific in vivo tumor targeting capabilities. Here, we report the design, synthesis, surface engineering, and in vivo active vasculature targeting of a new category of theranostic nanoparticle for future cancer management. Water-soluble photothermally sensitive copper sulfide nanoparticles were encapsulated in biocompatible mesoporous silica shells, followed by multistep surface engineering to form the final theranostic nanoparticles. Systematic in vitro targeting, an in vivo long-term toxicity study, photothermal ablation evaluation, in vivo vasculature targeted imaging, biodistribution and histology studies were performed to fully explore the potential of as-developed new theranostic nanoparticles.

Ablation Techniques

Animals

Antineoplastic Agents - chemistry

Antineoplastic Agents - pharmacology

Antineoplastic Agents - therapeutic use

Copper - chemistry

Copper - pharmacokinetics

Copper - therapeutic use

Drug Carriers - chemistry

Drug Carriers - pharmacokinetics

Drug Carriers - therapeutic use

Endoglin

Female

Heterocyclic Compounds - chemistry

Humans

Intracellular Signaling Peptides and Proteins - metabolism

Mammary Neoplasms, Experimental - blood supply

Mammary Neoplasms, Experimental - diagnostic imaging

Mammary Neoplasms, Experimental - metabolism

Mammary Neoplasms, Experimental - therapy

Mice

Nanostructures - chemistry

Neovascularization, Pathologic - therapy

Polyethylene Glycols - chemistry

Porosity

Positron-Emission Tomography

Silicon Dioxide - chemistry

Theranostic Nanomedicine - methods

Tissue Distribution

Details

Title: Subtitle: In Vivo Tumor Vasculature Targeting of CuS@MSN Based Theranostic Nanomedicine
Creators: Feng Chen - University of Wisconsin–Madison
Hao Hong - University of Wisconsin–Madison
Shreya Goel - University of Wisconsin–Madison
Stephen A Graves - University of Wisconsin–Madison
Hakan Orbay - University of Wisconsin–Madison
Emily B Ehlerding - University of Wisconsin–Madison
Sixiang Shi - University of Wisconsin–Madison
Charles P Theuer - Tracon Pharmaceuticals (United States)
Robert J Nickles - University of Wisconsin–Madison
Weibo Cai - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: ACS nano, Vol.9(4), pp.3926-3934
DOI: 10.1021/nn507241v
PMID: 25843647
PMCID: PMC4414921
NLM abbreviation: ACS Nano
ISSN: 1936-0851
eISSN: 1936-086X
Grant note: T32CA009206 / NCI NIH HHS T32 CA009206 / NCI NIH HHS R01 CA169365 / NCI NIH HHS P30CA014520 / NCI NIH HHS T32 GM008505 / NIGMS NIH HHS P30 CA014520 / NCI NIH HHS 1R01CA169365 / NCI NIH HHS
Language: English
Date published: 04/28/2015
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology
Record Identifier: 9984383888802771

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