In-office biopsy of upper airway lesions: safety, tolerance, and effect on time to treatment

Dylan Lippert; Matthew R Hoffman; Phat Dang; Timothy M McCulloch; Gregory K Hartig; Seth H Dailey

doi:10.1002/lary.25007

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In-office biopsy of upper airway lesions: safety, tolerance, and effect on time to treatment

Journal article

Peer reviewed

In-office biopsy of upper airway lesions: safety, tolerance, and effect on time to treatment

Dylan Lippert, Matthew R Hoffman, Phat Dang, Timothy M McCulloch, Gregory K Hartig and Seth H Dailey

The Laryngoscope, Vol.125(4), pp.919-923

04/2015

DOI: 10.1002/lary.25007

PMID: 25376857

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Abstract

Definitive tissue diagnosis for lesions warranting biopsy is shifting from the operating room to the office. Safety, tolerance, factors related to successful biopsy, and time to treatment are not well-defined. Retrospective review of 116 patients undergoing in-office biopsy of oropharynx, larynx, or hypopharynx were included. Logistic regression determined if demographics, site, T-stage, or approach (transoral/transnasal) were related to success. Time to definitive treatment was also analyzed. Ninety-two transnasal and 24 transoral biopsies were performed on 73 laryngeal, 35 oropharyngeal, and 8 hypopharyngeal lesions. Of those, 97 of 116 diagnoses were made in-office. There were no complications; two patients did not tolerate the procedure. Success was not related to age (P = 0.374), site (P = 0.527), T-stage (P = 0.587), or approach (P = 0.566). Time to treatment was 24.2 ± 13.9 days with successful office biopsy and 48.8 ± 49.4 days without. High procedural completion rate was observed across patients, sites, and approaches. All patients should be considered for in-office biopsy, a more time- and cost-effective option leading to earlier treatment.

Adult

Aged

Ambulatory Surgical Procedures - economics

Ambulatory Surgical Procedures - methods

Analysis of Variance

Biopsy, Needle - economics

Biopsy, Needle - methods

Chi-Square Distribution

Cohort Studies

Cost Savings

Female

Head and Neck Neoplasms - pathology

Head and Neck Neoplasms - surgery

Humans

Hypopharyngeal Neoplasms - pathology

Hypopharyngeal Neoplasms - surgery

Laryngeal Neoplasms - pathology

Laryngeal Neoplasms - surgery

Laryngoscopy - methods

Logistic Models

Male

Middle Aged

Operating Rooms

Operative Time

Oropharyngeal Neoplasms - pathology

Oropharyngeal Neoplasms - surgery

Patient Safety

Retrospective Studies

Risk Assessment

Sensitivity and Specificity

Details

Title: Subtitle: In-office biopsy of upper airway lesions: safety, tolerance, and effect on time to treatment
Creators: Dylan Lippert - University of Wisconsin–Madison
Matthew R Hoffman
Phat Dang - University of Wisconsin–Madison
Timothy M McCulloch - University of Wisconsin–Madison
Gregory K Hartig - University of Wisconsin–Madison
Seth H Dailey - University of Wisconsin–Madison
Resource Type: Journal article
Publication Details: The Laryngoscope, Vol.125(4), pp.919-923
DOI: 10.1002/lary.25007
PMID: 25376857
ISSN: 0023-852X
eISSN: 1531-4995
Language: English
Date published: 04/2015
Academic Unit: Otolaryngology
Record Identifier: 9984366370302771

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42 Times Cited - Web of Science

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